In order to study changes occurring on the surfaces of human endometrial epithelial cells in the presence of an implanted blastocyst, we used scanning electron microscopy for investigation of five endometrial biopsies and three human implantation sites obtained in vitro. All specimens showed areas with endometrial pinopodes, separated by cells displaying microvilli or cilia at the apical surfac...

The formation of endometrial pinopodes detected by scanning electron microscopy may be a specific marker for uterine receptivity. Aiming to assess the effects of ovarian stimulation on pinopode formation, we examined sequential endometrial biopsies from 17 oocyte donors. Seven normally menstruating women served as controls. Up to four samples were taken from each woman at 24-72 h intervals betw...

Abstract Study question Organoids from menstrual blood (MB) can mimic human receptive endometrium? Summary answer This research provides a reliable and less invasive 3D endometrial model able to the window of implantation (WOI). What is known already Investigating physiology function normal cycling endometrium challenging due its great individual variability. hEOs are considered new step forwar...

introduction: the aim of this study was to evaluate the expression of pinopodes as animplantation marker after ovarian hyper stimulation and progesterone injection using scanningelectron microscopic studies. material and methods: three groups of nmri adult female mice were used in the experiment. the control group (group a) were untreated pseudopregnant mice. group b mice were made pseudopregna...

Objective(s) Sildenafil citrate is a new drug and has special properties that bring about nitric oxide effects on vascular smooth muscle. The aim of this study was to assess the effects of ovarian stimulation and sildenafil citrate injection on pinopode expression in mice. Materials and Methods Thirty adult female mice were randomly divided into three groups: control, hyperstimulated and hyp...

Introduction Infertility is a condition that affects a couple and is defined as the lack of conception after an arbitrary period of 12 months with regular sexual intercourse and without using any contraception. Infertility is a common medical problem present in about 10% of couples in reproductive age. Tubal factor infertility (TFI) is one of the leading causes of infertility in the world inclu...

BACKGROUND Endometrial development has an important role in blastocyst adhesion and implantation. During IVF cycles, endometrial development is enhanced by progesterone. OBJECTIVE The aim of this study was to compare ultrastructural and morphometrical characteristics of mice uterine endometrium in natural cycle with those in superovulated cycles received progesterone or Sildenafil. MATERIAL...