Abstract During cancer and chronic viral infections, the persistence of antigen progressively causes CD8+ T cells to differentiate into a dysfunctional PD1+ “exhausted” state, with reduced production inflammatory cytokines relative effector that form during acute infections. Antigen costimulation signals activate kinase cascades induce distinct cell transcription programs, but how distinguish p...

Glioblastoma multiform is a primary brain tumor derived from glial cells. The aim of this study to investigate how glutamate metabolism regulated by transporter 1 (GLT-1) degradation pathway in glioblastoma and cell lines. protein expression levels GLT-1, total ubiquitin, kinase C (PKC) proteins involved the GLT-1 were measured western blot technique. Additionally, cells, level accumulated medi...

Abstract 10-Methyl-aplog-1 (1), a simplified analog of debromoaplysiatoxin, exhibits high binding affinity for protein kinase C (PKC) isozymes and potent antiproliferative activity against several cancer cells with few adverse effects. A recent study has suggested that its phenol group in the side chain is involved hydrogen bonding CH/? interactions cleft-forming loops PKC?-C1B domain. To clari...

Objective(s): Pathophysiology of sepsis-associated renal failure (one of the most common cause of death in intensive care units) had not been fully determined. The effect of nitric oxide and protein kinase C (PKC) pathways in isolated kidney of Lipopolysaccharide-treated (LPS) rats were investigated in this study. Materials and Methods: Vascular responsiveness to phenylephrine and acetylcholine...

When an experience is encrypted into a long-lasting memory, it is believed that specific sets of neurons in the brain of the animal undergo changes including the strengthening of preexisting synapses and the growth and maintenance of new synaptic connections. These activity-dependent synaptic changes appear to require the coordination of a variety of cellular processes in spatially separated ce...

ABSTRACT Fertilization triggers significant cellular remodeling through the oocyte-to-embryo transition. In this transition, ubiquitin-proteasome system and autophagy are essential for degradation of maternal components; however, significance cell surface components remains unknown. study, we show that multiple plasma membrane proteins, such as glycine transporter GlyT1a, selectively internaliz...

Introduction: Transient receptor potential vanilloid type 1 (TRPV1) and protein kinase Cγ (PKCγ) are involved in sensitization/desensitization to noxious stimuli. We aimed to examine the gene expression levels of TRPV1 and PKCγ in rat lumbosacral cord and midbrain on days 1, 4 and 8 of induction of morphine analgesic tolerance. Methods: Two groups of male Wistar rats received ...