primary dysmenorrhea is a prevalent issue and it can reduce the quality of life in many females worldwide. based on the properties of teucrium polium as a herbal medicine with analgesic and inflammatory properties, this triple-blind, randomized, placebo controlled trial was performed. the study aimed to evaluate the effects of teucrium polium on the severity of primary dysmenorrhea in students....

how to cite this article: abbaskhanian a, ehteshami s, sajjadi s, rezai ms. effects of piracetam on pediatric breath holding spells: a randomized double blind controlled trial. iran j child neurol autumn 2012; 6(4): 9-15.   abstarct: objective breath holding spells (bhs) are common paroxysmal non-epileptic eventsin the pediatric population which are very stressfull despite their harmlessnature....

background and aims: osteoarthritis is one of the most common arthritis in elderly. we evaluated to compare the effect of topical application of eugenia caryophylata extract and topical diclofenac in primary knee osteoarthritis.methods: this randomized double-blind clinical trial study was carried out upon 105 patients with primary knee osteoarthritis. patients were selected randomly and divide...

as the most common male sexual disorder premature ejaculation (pe), also referred to as early ejaculation (ee) or rapid ejaculation (re), affects 30%-40% of sexually active men. despite the limited number of available studies comparing the efficacy of selective serotonin re-uptake inhibitors (ssri) they have been thought to have beneficial effects for the treatment of patients with pe. in the p...

purpose: in this study the effect of iron supplmentation on hemoglobin and hematocrit in pregnant women with hb>13.2 g/dl was investigated. material and methods: in this experimental clincal study, the effect of iron supplementation on hemoglobin and hematocrit in pregnant women with hb>13.2 g/dl and ferritin> 14.3 μg/l during the 13th- 18th pregnancy week was studied. eighty seven women havin...

People who become hyperthermic during exercise display large increases in heart rate (HR) and reductions in stroke volume (SV). It is not clear if the reduction in SV is due primarily to hyperthermia or if it is a secondary effect of an elevation in HR reducing ventricular filling. In the present study, the upward drift of HR during prolonged exercise was prevented by a very small dose of the β...

Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...

In terms of advancement of life to meet the challenges new method for neuropsychopharmacological research are continually developing to ensure superior safety, accuracy, efficacy, precision etc. In this experiment, we suggested and validated two neuropsychopharmacological testing methods, these are Numeral Finding (NF) and Typo Revealing (TR) tests for the determination of attention in healthy ...

BACKGROUND The PCSK9 antibody alirocumab (75 mg every 2 weeks; Q2W) as monotherapy reduced low-density lipoprotein-cholesterol (LDL-C) levels by 47%. Because the option of a monthly dosing regimen is convenient, ODYSSEY CHOICE II evaluated alirocumab 150 mg Q4W in patients with inadequately controlled hypercholesterolemia and not on statin (majority with statin-associated muscle symptoms), rece...

BACKGROUND Preventive medication is indicated for many migraine patients, but is used in relatively few. The aim of the present study was to evaluate the efficacy of acetyl-l-carnitine as a prophylactic drug in migraine patients. METHODS A single-center, randomized, triple-blind, placebo-controlled, crossover study was carried out. Men and women, age 18-65 years, with episodic migraine but ot...