Verapamil has been shown to inhibit fentanyl uptake in vitro and is a potent P-glycoprotein inhibitor. Tissue partitioning of loperamide, a commercially available opioid, is closely controlled by the P-gp efflux transporter. The following studies were designed to evaluate the effect of opioids on verapamil partitioning in the lung and brain, in vivo. Opioid (fentanyl or loperamide) was administ...

Urban green space (UGS) can be regarded as an effective approach to mitigate urban heat island (UHI) effects. Many studies have investigated the impacts of composition and configuration UGS on land surface temperature (LST), while little attention has been paid among different blocks. Thus, taking 1835 blocks in Beijing samples, including low-rise point (LRP), street (LRS), block (LRB), mid-ris...

Bu araştırmada, 2012 ve 2018 arazi kullanım/arazi örtüsü (AKAÖ) haritaları kullanılarak Burdur İli Merkez İlçesi'nde peyzaj değişiklikleri incelenmiştir. Veri analizinde ArcMap 10.8 FRAGSTATSTM 4.2 yazılımlarından faydalanılmıştır. AKAÖ üzerindeki değişiklikler Sınıf Alanı (CA), Parça Sayısı (NP), Yoğunluğu (PD), Peyzajın Oranı (PLAND) Ortalama Büyüklüğü (AREA_MN) metrikleri belirlenmiştir. yıl...

The analysis of spatiotemporal changes landscape patterns is great significance for forest protection. However, the selection metrics often subjective, and existing composite rarely consider effects spatial correlation. A more objective approach to formulating involves proper weighting that incorporates structure information into integrating individual conventional selected building a metric. T...

In order to explore the change of Green Space in Suzhou, a central City in China's Yangtze River Delta, and reveal the spatial characteristics, ecological benefits and its impact mechanism, this study extracted a distribution map of the patches of green spaces in Suzhou using Landsat remote-sensing image data from 1998 and 2007, analyzed and assessed the changes in scale and spatial layout of t...

Context. The metallicity dependence of the Cepheid PL-relation is of importance in establishing the extra-galactic distance scale. Aims. The aim of this paper is to investigate the metallicity dependence of the PL-relation in V and K based on a sample of 68 Galactic Cepheids with individual Baade-Wesselink distances (some of the stars also have an HST-based parallax) and individually determined...

Increasing trends of urbanization lead to vegetation degradation in big cities and affect the urban thermal environment. This study investigated (1) the cooling effect of urban green space spatial patterns on Land Surface Temperature (LST); (2) how the surrounding environment influences the green space cool islands (GCI), and vice versa. The study was conducted in two Asian capitals: Beijing, C...