نتایج جستجو برای: plasminogen activator

تعداد نتایج: 52174  

Journal: :modares journal of medical sciences: pathobiology 2013
azam rahimpour behrouz vaziri farzaneh barkhordari leila nematollahi ahmad adeli

objective: development of high producing mammalian cell lines is a major bottleneck in manufacturing of recombinant therapeutic proteins. this study examines the effect of using the matrix attachment region from the human interferon beta gene in combination with promoter activation strategy with e1a 13s protein on human tissue plasminogen activator (t-pa) expression in chinese hamster ovary (ch...

Journal: :Gematologiia i transfuziologiia 2022

Introduction. The most widely accepted notion of the function blood clotting factor XII (FXII, Hageman factor) is its involvement in internal pathway. However, biological role FXII diverse. Aim – to review diverse functions FXII. Main findings. a serine protease. structure has high degree homology with plasminogen, tissue plasminogen activator and urokinase activator. Activated (FXIIa) five sub...

2017
Marlien Pieters Sunelle A Barnard Du Toit Loots Dingeman C Rijken

Due to controversial evidence in the literature pertaining to the activity of plasminogen activator inhibitor-1 in platelets, we examined the effects of residual platelets present in plasma (a potential pre-analytical variable) on various plasminogen activator inhibitor-1 and plasminogen activator inhibitor-1-related assays. Blood samples were collected from 151 individuals and centrifuged at 3...

Journal: :Gut 1993
C F Sier H W Verspaget G Griffioen S Ganesh H J Vloedgraven C B Lamers

Carcinogenesis in the human colon is associated with a marked increase of urokinase type plasminogen activator and a decrease of tissue type plasminogen activator. This study was performed to determine the concentrations of urokinase type plasminogen activator and tissue type plasminogen activator in normal tissue and carcinomas along the upper part of the gastrointestinal tract. Activity and a...

Journal: :Clinical Chemistry and Laboratory Medicine 2021

Article Elevated soluble urokinase plasminogen activator receptor (suPAR) in COVID-19 patients was published on October 1, 2021 the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 59, issue 11).

Journal: :Gut 1993
M A Wodziński K D Bardhan J T Reilly P Cooper F E Preston

The gastroduodenal mucosa has a rich blood supply. An active fibrinolytic system is presumably required to maintain vascular patency, and impairment may result in reduced blood flow, focal tissue necrosis, and peptic ulcerogenesis. Tissue type and urokinase type plasminogen activator activity (expressed as mIU/mg protein) and plasminogen activator inhibitor type-1 antigen were assayed in homoge...

Journal: :British heart journal 1988
J Aznar A Estellés G Tormo P Sapena V Tormo S Blanch F España

Several fibrinolytic variables, including plasminogen activator inhibitor activity, were studied before and after exercise in 67 normolipidaemic patients with coronary artery disease and in 25 hyperlipidaemic patients with coronary artery disease. Before exercise plasminogen activator inhibitor activity was higher in the patient groups than in a group of 10 healthy volunteers. For those who wer...

2012
Zaid H. Al-Hamodi Riyadh Saif-Ali Ikram S. Ismail Khaled A. Ahmed Sekaran Muniandy

The plasminogen activator inhibitor-1 4G/5G and tissue plasminogen activator Alu-repeat insertion/deletion polymorphisms might be genetic determinations of increased or decreased of their plasma activities. The aim of this study was to investigate the association of plasminogen activator inhibitor-1 4G/5G and tissue plasminogen activator Alu-repeat I/D polymorphisms with metabolic syndrome para...

Journal: :Annals of palliative medicine 2021

Background: To analyze the correlations between plasma coagulation factor VII (FVII), plasminogen activator inhibitor-1 (PAI-1), uric acid, and insulin resistance (IR) diabetic macroangiopathy (DMAP) in elderly patients with type 2 diabetes mellitus (T2DM).

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