BACKGROUND Plasminogen deficiency is a rare autosomal recessive disease, which is associated with aggressive periodontitis and gingival enlargement. Previously described treatments of plasminogen deficiency associated periodontitis have shown limited success. This is the first case report indicating a successful therapy approach consisting of a non-surgical supra- and subgingival debridement in...

The growth of Lewis lung carcinoma (LLC) was sustained in plasminogen-deficient mice when transplanted into the dorsal skin but was dramatically suppressed in another anatomic location, the footpad. This unanticipated negative effect of plasminogen deficiency on footpad tumor growth was entirely relieved by superimposing a deficit in fibrinogen. This finding was not simply an unusual feature of...

BACKGROUND AND PURPOSE Although 4% of cerebral infarcts in the young can be attributed to hematologic disturbances that predispose to thrombosis, the frequency of cerebral infarcts caused by prothrombotic states is not known. Recently, the association between cerebral infarction and deficiencies of elements of the natural anticoagulant system has been recognized. METHODS Thirty-six consecutiv...

patients. Blood 2006; 108: 3021–6. 12 Heinz C, Kremmer S, Externbrink P, Steuhl KP. Ligneous conjunctivitis in a patient with plasminogen type I deficiency-case report with review of literature. Klin Monbl Augenheilkd 2002; 219: 156–8. 13 Yohe SL, Reyes M, Johnson DA, Fry CL, Scribbick FW, Kinney MC. Plasminogen deficiency as a rare cause of conjunctivitis and lymphadenopathy. Am J Surg Pathol ...

Plasminogen is a key proenzyme in the fibrinolytic and thrombolytic systems. Congenital deficiency of plasminogen and molecular abnormality of plasminogen (dysplasminogenemia) have been reported in association with the thrombotic tendency in human. In dysplasminogenemia, the level of immunoreactive plasminogen is normal, although the functional activity is reduced. Human plasminogen gene spans ...

Disorders in the blood coagulation system play an important role development of cardiovascular pathology diabetes. Factors that cause them are hyperglycemia, insulin deficiency, resistance, dyslipidemia, oxidative stress. The most significant changes observed vascular-platelet link hemostasis. Diabetes is characterized by morphological and functional endothelium vessels. activity platelets incr...

Atypical hemolytic uremic syndrome (aHUS) is a rare, but severe thrombotic microangiopathy. In roughly two thirds of the patients, mutations in complement genes lead to uncontrolled activation of the complement system against self cells. Recently, aHUS patients were described with deficiency of the fibrinolytic protein plasminogen. This zymogen and its protease form plasmin have both been shown...

Plasminogen activator inhibitor-1 (PAI-1)-deficient transgenic mice have improved survival and less fibrosis after intratracheal bleomycin instillation. We hypothesize that PAI-1 deficiency limits scarring through unopposed plasminogen activation. If this is indeed true, then we would expect increased urokinase-type plasminogen activator (uPA) expression to result in a similar reduction in scar...