One of two Pt(IV)-activated propanenitriles in trans-[PtCl4(EtCN)2] is involved in platinum(IV)-mediated nitrile-imine coupling with the platinum(II)-based metallacycles [PtCl2{NH=C(NR2)N(Ph)C(=NH)N(Ph)C(NR2)=NH}] [R2 = Me2 (1a), C5H10 (1b)] yielding diplatinum products, whose structures depend on molar ratios between the reactants. At a 1 : 1 ratio, the mixed-valence platinum(II)/platinum(IV) ...

the present work describes the studies on the coordination behaviour of 4[n-(benzalidene) amino]antipyrine semicarbazone (baaps) (i), 4[n-(furfural)amino]antipyrine semicarbazone (ffaaps) (ii) and 4[n-(cinnamalidene)amino]antipyrine semicarbazone (caaps) (iii) in presence of dimethyl sulfoxide (dmso) or diphenyl sulfoxide (dpso) towards th4+ and uo22+ salts. all the complexes were isolated in n...

DNA-alkylating agents that are platinum complexes induce apoptotic responses and have wide application in cancer therapy. The potential for platinum compounds to modulate signal transduction events that contribute to their therapeutic outcome has not been extensively examined. Among the signal transducer and activator of transcription (STAT) proteins, Stat3 activity is frequently up-regulated i...

Platinum(II) anticancer drugs are among the most effective and often used chemotherapeutic drugs. In recent years, there has been increasing interest in exploiting inert platinum(IV) scaffolds as a prodrug strategy to mitigate the limitations of platinum(II) anticancer complexes. In this prodrug strategy, the axial ligands are released concomitantly upon intracellular reduction to the active pl...

Reports on toxic effects of platinum coordination complexes on the endocrine pancreas are missing with exception of cis-DDP itself (Goldstein et al 1983). Recently, oxoplatin (trans-dihydroxy-cis-dichlorodiammine-platinum [IV]) an oxygenated derivative of cis-DDP has been described by Presnov and Konovalova (1988), Fig. 1. As indicated by the maximally tolerated dose levels, oxoplatin has been ...

Twenty two new Pt(II) and Pt(V) complexes with 3.5-disubstituted hydantoins and spiro-5’hydantoins were synthesized and studied. Pt(II) complexes have been prepared as structural analogues of cisplatin with different carrier ligands. Pt(IV) complexes were with general formula cis-[PtL2Cl4]. Platinum complexes were studied in vitro for cytotoxic activity on panel of human tumor cell lines. The c...

Breast cancer is a major health problem among women in the world. The successful treatment of this disease is limited by the fact that essentially all breast cancers become resistant to chemotherapy. Therefore, there is a need to design new chemotherapeutic agents able not only to target breast cancer but also to display increased efficacy and overall decreased systemic toxicity. Platinum (II) ...