conclusions globally, interventions that comprise evidence-based prevention, care and treatment of substance use disorders in young adults are vital to reduce the transmission of hiv infection and promote good clinical outcomes for young adults at-risk for living with hiv. context young adults comprise roughly one-quarter of the global population and are at the developmental stage where persona...

in this research, hydrogels based on poly vinyl alcohol and poly acrylic acid blend were prepared which were cross-linked by applied thermal conditions. afterward, effects of time and heating on water uptake were investigated. the highest water uptake value exhibited by the sample that was heated for 20 min. at 110 ºc was about 2129% after 4 days at equilibrium state. hydrogels exhibited ph-sen...

Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactid...

Bevacizumab (Avastin(®)) has been used by ophthalmologists in many countries as an off-label drug for the treatment of wet age-related macular degeneration (AMD). Due to its short half-life necessitating frequent intravitreal injection, a method for sustained delivery is in need. We demonstrated that bevacizumab could be released in a sustained fashion over 90 days from nano- and microspheres f...

in order to investigate the effect of pharmacist intervention on vancomycin use, this study was performed on all patients receiving vancomycin in the intensive care unit (icu) and hematology-oncology ward of taleghani educational hospital in tehran, iran. vancomycin use was assessed during a pre- and post-intervention period in accordance with the center of disease control and prevention (cdc) ...

Background: High prevalence of risky behaviors in alcohol dependents have been shown in several studies, but correlation between alcohol abuse and risky behaviors and relapse in patients with opiate dependence has been less investigated. This study aimed to determine the effect of alcohol abuse in rate of risk-taking behaviors in opiate dependents patients treated on maintenance program in Nort...

orally disintegrating tablets (odts) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. the aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...