The regulation of erythropoiesis was control cultures. Erythropoietin was studied in patients with polycythemia ineffective in stimulating iron incorpovera and chronic granulocytic Ieukeration into heme in five patients with mia (CGL). An in vitro culture system polycythemia vera. The marrow rewas employed to determine the response to erythropoietin in vitro was sponse of bone marrow cells to e...

Polycythemia vera is a chronic progressive myeloproliferative disease characterized by increased circulating red blood cells, and the hyperviscosity of the blood can lead to an increased risk of arterial thrombosis. In a previous survey regarding postoperative outcomes in polycythemia vera patients, an increased risk of both vascular occlusive and hemorrhagic complications have been reported. A...

We describe the course and likely pathophysiology of impending anterior ischemic optic neuropathy (AION) and retinal vein occlusion in a 56-year-old man with polycythemia vera managed with interferon alpha for 2 years. Our patient presented with decreased vision, scintillating scotomata, and floaters. Fundus examination findings and results of a fluorescein angiogram led to the diagnosis of imp...

PATIENT Female, 64 FINAL DIAGNOSIS: Polycythemia rubra vera Symptoms: Burning pain • cramps • hypesthesia • itching • paresthesia MEDICATION - Clinical Procedure: - Specialty: Neurology. OBJECTIVE Unusual clinical course. BACKGROUND The association between polycythemia vera and peripheral neuropathy has been described previously but only as a late complication and only with sensory axonal...

ary polyeythemia is diagnosed when the patient has polycythemia associated with cyanotic heart disease or lung disease in the absence of leukoeytosis, high platelet count, and splenic enlargement. The differentiation of polycythemia vera from secondary polycythemia is sometimes a difficult task. Ratto, Briscoe, Morton, and Comroel have discussed the theoretical reasons that make this distinctio...

Serum ESF titers were measured in 42 polycythemic patients using the fetal mouse liver cell bioassay. ESF titers in patients with secondary polycythemia differed significantly from those in patients with polycythemia vera (p less than 0.0001). Among the 21 patients with secondary polycythemia, 1 patient had an ESF titer less than 10 mU/ml (the lower limit of sensitivity) and 20 had ESF titers t...

dum-Nielsen K. Clonal Ph-negative hematopoiesis in CML after therapy with imatinib mesylate is frequently characterized by trisomy 8. Leukemia 2002;16:1390-3. 44. Cashman J, Henkelman D, Humphries K, Eaves C, Eaves A. Individual BFU-E in polycythemia vera produce both erythropoietin dependent and independent progeny. Blood 1983;61:876-84. 45. Levin J, Cocault L, Demerens C, Challier C, Pauchard...

Our knowledge of the genetic basis of these disorders began in 2005, when a unique base substitution in JAK2, the gene encoding Janus kinase 2,was found inpatientswith polycythemia vera, essential thrombocythemia, and primary myelofibrosis. The background of our investigations was the previous finding that copy-neutral loss of heterozygosity of chromosome 9p (9pLOH) is the most common chromosom...

Polycythemia vera is a clonal disorder arising in a multipotent hematopoietic progenitor cell that causes the accumulation of morphologically normal red cells, white cells, platelets, and their progenitors in the absence of a definable stimulus and to the exclusion of nonclonal hematopoiesis.1,2 First described in 1892,3 polycythemia vera is not a new disease and while uncommon, with an inciden...

INTRODUCTION Angiomyolipoma is a common benign renal tumor composed of thick-walled blood vessels, smooth muscle, and adipose tissue. It may be found incidentally during workup for suspected renal disease. Although angiomyolipoma may present as a palpable, tender renal mass with flank pain and gross or microscopic hematuria, many patients are asymptomatic. Erythrocytosis is an unusual presentat...