The synthesis and photophysical properties of water-soluble, fluorescent polyglycerol-dendronized perylenediimides 1-4 are reported. The polyglycerol dendrons, which are known to be highly biocompatible, are found to confer high water-solubility on the perylenediimide in aqueous media while retaining its excellent fluorescent properties. Furthermore, intramolecular cross-linking of the polyglyc...

Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell prolife...

The fast and simple method for total chlorine determination in polyglycerols using low resolution inductively coupled plasma mass spectrometry (ICP-MS) without the need for additional equipment and time-consuming sample decomposition was evaluated. Linear calibration curve for 35Cl isotope in the concentration range 20-800 µg/L was observed. Limits of detection and quantification equaled to 15 ...

Synthesis of novel aliphatic biodegradable copolyesters namely Poly (ethylene sebacateco-butylene succinate) and Poly (ethylene sebacate-co-butylene adipate) were carried out using Poly (butylene Succinate), Poly (Butylene Adipate) and Poly (Ethylene Sebacate) in presence of Poly Phosphoric acid. Synthesis of Poly (Butylene Succinate), Poly (Butylene Adipate) and Poly (Ethylene Sebacate) were c...

AIMS The goal of the experiment was to verify bioavailability of immunosuppressive drug cyclosporine after oral administration, to determine, in particular, effect of triglycerides and polyglycerol esters on bioavailability of this lipophilic, poorly soluble drug. METHODS 1) Absorption of cyclosporine A from soya oil and polyglycerol-3-oleate was tested after intra-duodenal application to rat...

In the title compound, [Co(C10H16O4)] n , the Co(II) atom is bonded in a slightly distorted tetra-hedral environment by four O atoms from the bridging sebacate dications, comprising two separate half-ligands which lie across crystallographic inversion centres. In the three-dimensional network coordination polymer, there are two different spatial extensions of Co(II) atoms, one with the Co(II) a...

A polyglycerol dendrimer (PGD) of generation 2, which consists of only glycerol units, constructed nanospace capable of uptake of a fluorescent molecule with a 1:1 stoichiometry. On the other hand, a PGD of generation 1 trapped the molecule at the outer part.

The development of living heart valves that grow with the patient is a promising strategy for heart valve replacements in pediatric patients. Despite active research in the field of tissue engineered heart valves there have been limited efforts to optimize the balance between biodegradation of the scaffolds and de novo extracellular matrix (ECM) synthesis by cells and study their consequences o...

Perfluoroalkyl-functionalized, hyperbranched polyglycerols that produce stable microbubbles are integrated into a microfluidic emulsion to create porous microspheres. In a previously-presented work a dendrimer with a perfluorinated shell was used. By replacing this dendrimer core with a hyperbranched core and evaluating different core sizes and degrees of fluorinated shell functionalization, we...