INTRODUCTION Extensively used polymers in biomedical applications are naturally occurring or synthetic compounds consisting of large molecules obtained from linking of simple monomers. Potential biomedical applications of these polymers include carrier based drug delivery systems, tissue engineering scaffold and cell culture supports [1]. Polymer based drug delivery system can control the rate ...

Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders ex vivo. The experiment was repeat...

BACKGROUND Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. MATERIALS AND METHODS Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylact...

Preventive and regenerative techniques have been suggested to minimize the aesthetic functional effects caused by intraoral bone defects, enabling installation of dental implants. Among them, porous three-dimensional structures (scaffolds) composed mainly bioabsorbable ceramics, such as hydroxyapatite (HAp) β-tricalcium phosphate (β-TCP) stand out for reducing use autogenous, homogeneous, xenog...

In this study, a new type of amphiphilic cetylated polyethyleneimine (PEI) was synthesized, and then polylactic-co-glycolic acid (PLGA)/cetylated PEI/hyaluronic acid nanoparticles (PCPH NPs) were developed by self-assembly as a novel type of gene-delivering vehicle. The PCPH NPs showed good DNA-condensation ability by forming polyplexes with small particle size and positive zeta potential. The ...

Dural defect is a common problem in neurosurgery, and the emergence of expanded polytetrafluoroethylene material provides an effective solution for rehabilitation artificial blood vessels, heart patches, other fields. However, studies on repair dura have reported occurrence adverse events cerebrospinal fluid leakage. Therefore, task improving materials cannot be delayed. In this study, new comp...

Tensile stress and tensile strain directly affect the quality of nerve regeneration after bridging nerve defects by poly(lactic-co-glycolic acid) conduit transplantation and autogenous nerve grafting for sciatic nerve injury. This study collected the sciatic nerve from the gluteus maximus muscle from fresh human cadaver, and established 10-mm-long sciatic nerve injury models by removing the isc...

The eye is a well-suited organ for local delivery of therapeutics to treat vitreous inflammation as well as other pathologic conditions that induce visual loss. Several conditions are particularly challenging to treat and often require chronic courses of therapy. The use of implantable intravitreal devices for drug delivery is an emerging field in the treatment of vitreous inflammation as well ...