Extracellular and intracellular barriers typically prevent non-viral gene vectors from having an effective transfection efficiency. Formulation of a gene delivery vehicle that can overcome the barriers is a key step for successful tissue regeneration. We have developed a novel core-shelled DNA nanoparticle by invoking solvent-induced condensation of plasmid DNA (beta-galactosidase or GFP) in a ...

The purpose of this study was to demonstrate that the ultrasonic energy used to melt the tip of an absorbable polylactide Pin (SonicPin) does not have a significant effect on the chemical characterization and associated degradation properties of the material. The results indicate that the polylactide Pin after ultrasound is chemically equivalent to the SonicPin prior to ultrasound with regard t...

Two very rapid yttrium initiators for lactide polymerisation are reported; the nuclearity (monomer vs. dimer) of the initiator controls the stereochemistry of the polylactide produced.

The reaction of N,N'-dibenzyl-2-amino-4-imino-pent-2-ene, nacnac(Bn)H, with 1 or 2 equiv. of MgnBu₂ afforded the homoleptic complex nacnac(Bn)₂Mg. The reaction of nacnac(Bn)H with Mg(N(SiMe₃)₂)₂ yielded nacnac(Bn)MgN(SiMe₃)₂, which reacted with tert-butanol to form nacnac(Bn)MgOtBu. The latter complex crystallizes as an alkoxide bridge dimer and is active in the ring-opening polymerisation of r...

This work deals with the preparation and characterization of antimicrobial polymeric composite materials based on polylactide, which is currently widely investigated to produce temporary implants. Polylactide was blended fillers: silver, hexadecylpyridinium or hexadecyltrimethylammonium bromides anchored vermiculite graphene oxide matrices in an amount 1% wt. The prepared samples were character...

Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG and N-(2-((trimethylsilyl)amino)ethyl)-5-norbornene-endo-2,3-dicarboximide (M1) followed by ring-opening polymerization of amino acid N-carboxya...

Of the various synthetic biodegradable polymers, polylactide, poly(butylene succinate), and poly(hydroxyalkanoate) have been widely studied developed. This review focuses on studies of chain end modification these polymers. The selected research was categorized into initiators, modification, including extending, degradation reaction. We cover recent literature this topic, discuss developing tre...

Our continuing research on the preparation, characterization, materials properties, and biodegradability of polylactide (PLA)/organically modified layered silicate (OMLS) nanocomposites has yielded results on PLA/montmorillonite nanocomposites. Montmorillonite (mmt) modified with dimethyldioctadecylammonium cation was used as an OMLS for nanocomposite preparation. The internal structure of nano...