Oritavancin, a semisynthetic lipoglycopeptide with activity against gram-positive bacteria, has multiple mechanisms of action, including the inhibition of cell wall synthesis and the perturbation of the membrane potential. Approved guidelines for broth microdilution MIC assays with dalbavancin, another lipoglycopeptide, require inclusion of 0.002% polysorbate 80. To investigate the potential im...

OBJECTIVE To assess the vasodilating effects of amiodarone on canine coronary arteries by using solutions of amiodarone dissolved in polysorbate 80 or water. METHODS Rings of coronary arteries, with or without intact endothelium, were immersed in Krebs solution and connected to a transducer for measuring the isometric force promoted by a vascular contraction. The arteries were exposed to incr...

The chemical composition of polysorbate 80 strongly influences the physicochemical properties and performance of many products. Consequently, a reliable characterization of polysorbate 80 is crucial for many applications. However, the exact composition of these chemical mixtures cannot be determined by colorimetry, hydrolysis, size-exclusion chromatography, nuclear magnetic resonance or mass sp...

Each mL of these preparations contains: Methylprednisolone acetate..................................20 mg Polyethylene glycol 3350.....................................29.5 mg Polysorbate 80 .....................................................1.97 mg Monobasic sodium phosphate ...............................6.9 mg Dibasic sodium phosphate USP...........................1.44 mg Benzyl alcohol add...

Degradation of Polysorbate 20 (PS20), a commonly used surfactant in drug product (DP) formulations, is phenomenon increasing concern to the biopharmaceutical industry. One most prevalent modes PS20 degradation enzymatic hydrolysis resulting from co-purified hydrolases that make their way into biologic DP formulations at trace levels. Enzymatic results generation free fatty acids (FFAs) have lim...

Lipitor tablets for oral administration contain 10, 20, 40 or 80 mg atorvastatin and the following inactive ingredients: calcium carbonate, USP; candelilla wax, FCC; croscarmellose sodium, NF; hydroxypropyl cellulose, NF; lactose monohydrate, NF; magnesium stearate, NF; microcrystalline cellulose, NF; Opadry White YS-1-7040 (hypromellose, polyethylene glycol, talc, titanium dioxide); polysorbat...

BACKGROUND Previously we showed that the release properties of a liposomal ciprofloxacin (CFI) formulation could be attenuated by incorporation of drug nanocrystals within the vesicles. Rather than forming these drug nanocrystals during drug loading, they were created post manufacture simply by freezing and thawing the formulation. The addition of surfactant to CFI, either polysorbate 20 or Bri...

Each mL of these preparations contains: Methylprednisolone acetate.............................. 20 mg Polyethylene glycol 3350....................................29.5 mg Polysorbate 80 ....................................................1.97 mg Monobasic sodium phosphate ..............................6.9 mg Dibasic sodium phosphate USP..........................1.44 mg Benzyl alcohol added as a...