Angiotensin converting enzyme (ACE; OMIM: 106180) has an important role in the conversion of angiotensin I to angiotensin II and degradation of bradykinin. Genetic polymorphism I/D (rs4646994) in the gene encoding ACE has been well defined. To get more insight into the genetic structure of Iranian populations, the distribution of the ACE I/D polymorphism among Iranians was compared with each ot...

background: determining of gene frequencies of a, band 0 genes from abo blood group system and d and d genes from rhesus system are objectives of the present study. methods: the study was a cross sectional descriptive study. all the voluntary blood donors, 7361 people, attending to the hamadan, iran, blood bank during 1996 were studied. primary information from the sex of blood donors and their...

Evolutionary genetics studies the patterns and mechanisms of genetic changes underlying evolutionary change. Because biological diversity at all levels (including population, species, and ecosystem diversity) has a genetic basis and is a result of evolution, evolutionary genetics provides insight into the ultimate mechanisms creating biodiversity. Evolutionary genetics utilizes empirical tools ...

David B. Goldstein is Professor of Genetics in the Galton Laboratory, Department of Biology, at University College London. His training is in population genetics, and his primary contributions have been in assessing the medical and evolutionary implications of human genetic diversity. His work currently focuses on pharmacogenetics, the genetics of complex disease, and human evolution. He receiv...

Population genetics is the study of genetic variability within a population and of the forces that act upon it. As well as being of central importance to our understanding of evolution from prehistoric to modern times, it now also affects our everyday lives — whether considering human genetic disease, how to avoid the extinction of rare species or the merits of ‘DNA fingerprinting’ in forensic ...