The growth of the membrane technologies has fell far behind the initial anticipation, one of the major obstacles, which hinders more widespread of its application, is that the filtration performance inevitably decreases with filtration time. This phenomenon is commonly termed as membrane fouling, which refers to the blockage of membrane pores during filtration by the combination of sieving and ...

Petiolar application of potassium cyanide inhibited (14)C-assimilate translocation without affecting source leaf photosynthesis or phloem loading of sucrose in Phaseolus vulgaris. The inhibition of transport was correlated with disruption of the structural integrity of the sieve tubes (sieve pore blockage) rather than impairment of a metabolic process in the translocation path driving transloca...

Emergent rational drug design techniques explore individual properties of target biomolecules, small and macromolecule drug candidates, and the physical forces governing their interactions. In this minireview, we focus on the single-molecule biophysical studies of channel-forming bacterial toxins that suggest new approaches for their inhibition. We discuss several examples of blockage of bacter...

Vpu is an 81-residue membrane protein, with a single transmembrane segment that is encoded by HIV-1 and is involved in the enhancement of virion release via formation of an ion channel. Cyclohexamethylene amiloride (Hma) has been shown to inhibit ion channel activity. In the present 12-ns simulation study a putative binding site of Hma blockers in a pentameric model bundle built of parallel ali...

The present paper aims to study the effect of partial blocking and flow regime on mutual turbulent interplay between porous non-porous regions in packed bed energy storage systems (PBESSs). To this end, high-fidelity pore-scale large eddy simulations (LES) are conducted for two PBESS configurations, namely full blockage under discharge process at three Re numbers 3600, 7200, 14,400. influences ...

The propagation of waves in fluid-saturated porous periodic structures is significantly affected by the interface condition between adjacent layers. We consider this paper partial-open pore layers a one-dimensional phononic crystal. A transfer matrix method devised to obtain both complex band structure and poroelastic Bloch Spectral transmission through finite further computed stiffness method....

Proapoptotic phosphorothioate oligonucleotides such as G3139 (an 18-mer) induce Bcl-2-independent apoptosis, perhaps partly via direct interaction with VDAC and reduction of metabolite flow across the mitochondrial outer membrane. Here, we analyzed the interactions at the molecular level. Ten micromolar G3139 induces rapid flickering of the VDAC conductance and, occasionally, a complete conduct...