HANSON, KENNETH M., AND PAUL C. JOHNSON. 4kzzl control of hepatic arterial and portal uenous jaw in the dog. Am. J. Physiol. 211(3): 712-720. I g66.-Hemodynamic studies were made in over IOO experiments on the denervated, autoperfused, dog liver in situ. Electromagnetic flowmeters were used. Data\ are given on pressure-flow relationships in both vascular circuits, with and without simultaneous ...

Obstruction of the hepatic venous outflow tract results in increased hepatic sinusoidal pressure and portal hypertension. In the early stages, portal venous perfusion of the liver is decreased, which may result in portal venous thrombosis. 2 The ensuing venous stasis and congestion lead to hypoxic damage to adjacent hepatic parenchymal cells. Furthermore, the ischemic injury to the sinusoidal l...

We report the cases of two renal transplant recipients suffering from idopathic portal hypertension, a condition characterised by increased portal venous pressure in the absence of both histological lesion of the liver and obstruction of the portal vein. In these two patients, perisnusoidal fibrosis, invisible by light microscopy, was demonstrated by electron microscopy; it is suggested that pa...

MITZNER, WAYNE. Hepatic outJrow resistance, sinusoid pressure, and the vascular waterfall. Am. J. Physiol. 227(3): 513-519. 1974.The pressure-flow characteristics of the hepatic common outflow resistance were determined in five anesthetized dogs. These curves were shown to be nearly linear in the range of normal flows, but exhibited a moderate convexity toward the pressure axis at low flows. Th...

Portal hypertension is defined by the hepatic venous pressure gradient and is measured via a percutaneous transhepatic route [1]. We describe a novel technique for direct portal pressure measurement using endoscopic ultrasound (EUS). A 27-year-old man with Noonan syndrome and congenital heart disease presented with recurrent gastrointestinal bleeding. EUS revealed an extensive network of peridu...

This report presents the case of a 78-year-old female with hepatic encephalopathy due to an inferior mesenteric venous-inferior vena cava shunt. She developed hepatocellular carcinoma affected by hepatitis C virus-related cirrhosis and underwent posterior sectionectomy. Portal vein thrombosis developed and the portal trunk was narrowed after hepatectomy. Portal vein thrombosis resulted in high ...

The effects on portal pressure of the vasodilatory drugs isosorbide dinitrate and verapamil and of an alpha and beta blocking agent, labetalol, were assessed in 21 patients with cirrhosis and portal hypertension. The wedged hepatic venous pressure gradient (wedged minus free hepatic venous pressures) was used as an index of portal pressure and was not significantly changed by treatment with lab...

Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12.8 (5.3) mm Hg (normal values less than 5 mm Hg). All patients but one had increased portal pressure gradient. Portal hypertension correlated...

Portal hypertension (PHT) is a complication of liver cirrhosis and directly increases mortality and morbidity by increasing the propensity of venous hemorrhage. There are two main underlying causations for PHT, increased hepatic resistance and systemic hyperdynamic circulation. Both are related to localized aberrations in endothelial nitric oxide synthase (eNOS) function and NO biosynthesis. Th...

We determined the constrictive effects of endothelin (ET)-1 on the hepatic vascular resistance distribution and the receptor subtype responsible for the effect in isolated rabbit livers perfused via the portal vein with 5% albumin-Krebs solution. The sinusoidal pressure was estimated using the double vascular occlusion pressure. The basal portal venous resistance comprised 59% of the total port...