mirtazapine is a new antidepressant that can increase noradrenergic and serotonergic neurotransmission. it is also a postsynaptic antagonist of 5-ht2 and 5-ht3. in addition, it has only a weak affinity for 5-ht1 receptors and has very weak muscarinic anticholinergic and histamine (h1) antagonist properties. we report a case of hypertensive urgency that ensued after a patient took a single low d...

Recent research has deconstructed the concept of impulsivity by identifying five different traits that influence engagement in impulsive behaviors: positive urgency (tendency to act rashly in response to a positive mood), negative urgency (tendency to act rashly in response to a negative mood), sensation seeking, lack of planning, and lack of perseverance. The traits are only moderately related...

This study aims to explore the relationship between impulsivity traits and perceived negative consequences of alcohol consumption and Internet use. More specifically, impulsivity traits - positive and negative urgency, sensation seeking, lack of premeditation, and lack of perseverance - in (1) the occurrence of initial negative consequences linked to use, and (2) the transition from consequence...

Positive urgency, the tendency to respond impulsively to positive affective states, has been linked to many psychopathologies, but little is known about mechanisms underpinning this form of impulsivity. We examined whether the Positive Urgency Measure (PUM) related to higher scores on performance-based measures of impulsivity and cognitive control that were administered after a positive mood in...

OBJECTIVE To study the role of women's position as a stimulus of urgency, and specifically the change of position, i.e. to stand up form a lying or sitting position. Thus, we compared clinical and urodynamics characteristics among women with overactive bladder syndrome (OAB) depending of the position which could trigger urgency. METHODS Thirty-eight females with complaints of urgency, without...

OBJECTIVE Bipolar disorder has been associated with elevated impulsivity - a complex construct subsuming multiple facets. We aimed to compare specific facets of impulsivity in bipolar disorder, including those related to key psychological correlates of the illness: reward sensitivity and strong emotion. METHOD Ninety-one individuals diagnosed with bipolar I disorder (inter-episode period) and...

Approach, avoidance and the supervisory control system are fundamental to human behavior. Much past research has examined the neurophysiological models relating trait approach and avoidance. Using measures of electroencephalographic (EEG) frontal asymmetry, trait approach has been associated with greater left-frontal activity and trait avoidance has been associated with greater right-frontal ac...