Background and Aims: The object of this study was the investigation central antinociceptive effects naringin as well association stimulation opioidergic, serotonergic, adrenergic, cholinergic (muscarinic nicotinic) receptors to analgesia mice due naringin. Methods: Several intraperitoneal doses (20, 40, 80 mg/kg) were injected into models analyzed via hot-plate (integrated supraspinal response)...