Preterm birth (PTB) is a live birth delivered before 37 weeks of gestation (GW). About one-third of PTBs result from the preterm premature rupture of membranes (PPROM). Up to the present, the pathogenic mechanisms underlying PPROM are not clearly understood. Here, we investigated the differential expression of long chain non-coding RNAs (lncRNAs) in placentas of PTBs with PPROM, and their possi...

OBJECTIVE This study aimed to investigate the role of various biochemical markers in preterm premature rupture of membranes (PPROM) and in prediction of chorioamnionitis in patients with PPROM. MATERIAL AND METHODS This case-control study included a total of 100 pregnant women at 26-34 gestational weeks. Of these women, 50 were healthy and 50 had PPROM. The biochemical markers in the maternal...

BACKGROUND The role of viral infections in preterm prelabor rupture of the membranes (PPROM) is not established. Studies on the presence of viral genomes in the amniotic fluid (AF) collected in pregnancies complicated by PPROM show contradictory outcomes. OBJECTIVES To investigate AF samples of PPROM pregnancies for the presence of viral genomes. STUDY DESIGN AF samples from patients with P...

Methods We identified 76 women with twin pregnancies who were diagnosed as having PPROM and a delay to delivery greater than 24 hours, over a six year period at one centre. Demographic characteristics and risk factors for preterm labour and PPROM were evaluated for all women. We compared the length of time from rupture of membranes to delivery and subsequent neonatal morbidity and mortality res...

OBJECTIVE To characterize the vaginal microbiota of women following preterm premature rupture of membranes (PPROM), and determine if microbiome composition predicts latency duration and perinatal outcomes. DESIGN A prospective cohort study. SETTING Canada. POPULATION Women with PPROM between 24+0 and 33+6 weeks gestational age (GA). METHODS Microbiome profiles, based on pyrosequencing o...

BACKGROUND Pre-term birth (PTB) remains the leading cause of infant mortality and morbidity. Its etiology is multifactorial, with a strong genetic component. Genetic predisposition for the two subtypes, spontaneous PTB with intact membranes (sPTB) and preterm prelabor rapture of membranes (PPROM), and differences between them, have not yet been systematically summarised. METHODS AND FINDINGS ...

The purpose of this study was to determine cord blood cytokine levels and their relationship with morbidity and mortality in neonates with prolonged, premature rupture of membranes (PPROM). Forty two premature neonates of 29-35 weeks gestational age with PPROM exceeding 24 hours were considered as the PPROM group and simultaneously, 41 premature neonates without PPROM were considered as the con...

OBJECTIVE To identify the risk factors for cystic periventricular leukomalacia (cPVL) and their implications for deciding between immediate delivery and conservative management of preterm prelabor rupture of the membranes (pPROM). METHODS The following risk factors were compared between cPVL infants and 6440 controls: chorioamnionitis, sex, gestational age (GA), birth weight, pPROM, and pPROM...

The premature rupture of membranes (PROM), defined as rupture of the amniotic membranes before the onset of labor, remains a serious challenge for obstetricians, because of its high rate of comorbidity, including infection, cesarean section, and other associated problems. Preterm PROM (PPROM) (occurring before the 37 full gestational weeks), accompanied by preterm birth, is the leading cause of...

BACKGROUND Preterm premature rupture of membranes (PPROM) is responsible for one third of all preterm births (PTBs). We have recently demonstrated that long noncoding RNAs (lncRNAs) are differentially expressed in human placentas derived from PPROM, PTB, premature rupture of the membranes (PROM), and full-term birth (FTB), and determined the major biological pathways involved in PPROM. METHOD...