Ischemic heart disease (including coronary arterial atherosclerosis, or vascular cavity stenosis or occlusion) remains the leading cause of disease‑associated mortality worldwide. Prazosin, a receptor blocker of postsynaptic adrenaline, is essential in expanding peripheral arteries, which decreases peripheral vascular resistance, and regulates anti‑hypertensive action. However, the mechanisms u...

One hundred cases of hypertension were investigated and treated with Prazosin alone, Prazosin with a diuretic and Prazosin, Diuretic and a Beta-adrenergic blocker. They were followed up for two and more than two years. Prazosin was found to be very safe and effective antihypertensive drug either alone or in combination with a Diuretic, or Beta-adrcnergic blocker in various grades of hypertensio...

Posttraumatic stress disorder (PTSD) is a high-priority treatment area for the Veterans Health Administration (VHA), and dissemination patterns of innovative, efficacious therapies can inform areas for potential improvement of diffusion efforts and quality prescribing. In this study, we replicated a prior examination of the period prevalence of prazosin use as a function of distance from Puget ...

The left ventricular (LV) and coronary vascular effects of prazosin, a drug that reduces peripheral vascular resistance by blocking postsynaptic a receptors, were examined in conscious dogs. Prazosin, 0.07 mg/kg/mmn i.v. for 7 minutes, induced sustained hypotensive effects for more than 12 hours. The peak effects occurred 3045 minutes after administration. Prazosin increased heart rate by 28 ± ...

1. The effects of prazosin administered alone or in combination were studied in thirty patients between August 1974 and March 1975. 2. All patients had previously received treatment for hypertension with other agents, for from 2 months to 10 years. All thirty patients had refractory hypertension which had not responded satisfactorily to other treatment. 3. Patients were treated initially with p...

In light of the high prevalence of sleep disorders in patients suffering from post-traumatic stress disorders (PTSD), this study sought to comparing the effect of prazosin and hydroxyzine on sleep quality in this patient group. A total 100 patients suffering from PTSD were assessed (mean age: M = 35.51, SD = 6.41 28% females). Next, they were randomly assigned to one of three treatment groups: ...

1. We studied the effect of oral prazosin on blood pressure, plasma active renin and angiotensin II in 16 recumbent hypertensive patients between 09.00 and 12.00 hours. 2. In untreated patients there were no significant changes in blood pressure, plasma active renin or angiotensin II during the 3 h period. 3. After an initial dose of prazosin (2 mg) there was a significant fall in recumbent blo...

introduction: anxiety is among the most common and treatable mental disorders. adrenergic and cannabinoid systems have an important role in the neurobiology of anxiety. the elevated plus-maze (epm) has broadly been used to investigate anxiolytic and anxiogenic compounds. the present study investigated the effects of intraperitoneal (ip) injection of cannabinoid cb1 receptor antagonist (am251) i...

1. The interaction between prazosin and clonidine was studied in anaesthetized rats, pithed rats and in anaesthetized cats. 2. Prazosin diminished the clonidine-induced hypotensive effect in anaesthetized rats, probably via an antagonism at the level of central alpha-adrenoreceptors. 3. In pithed rats, stimulation of the Nervi accelerantes caused tachycardia, which was diminished considerably b...