Aim: To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of Olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug:carrier ratios such as 1:1, 1:2, 1:4, 1:6, 1:8 and 1:10 were tried for optimization. Characterization was done by phase solubility, in vitro release, saturation solubility, permeation, wetta...

Powder blend homogeneity is a critical attribute in formulation development of low dose and potent active pharmaceutical ingredients (API) yet a complex process with multiple contributing factors. Excipient characteristics play key role in efficient blending process and final product quality. In this work the effect of excipient type and properties, blending technique and processing time on con...

Ampelomyces quisqualis CPA-9 was reported as a promising biocontrol fungus against powdery mildew on cucurbits, although its formulation had not been developed. The present work aimed to develop fluidised-bed spray-dried of that included film-forming compounds, which could improve the behaviour microorganism under practical conditions. Film forming efficacy, shelf life, physical stability funct...

in this study, modified starch was used as a fat replacer in the milk. the fat replacer was manufactured from modified starch such as pre-gelatinized and cross–linked starches. modified starches were manufactured by hydrochloric acid and citric acid treatments from potato and wheat and were added to skim milk at concentrations of 0.15%, 0.30% and 0.45%. viscosity, total solid, fat content, titr...

The objective of this study was to find innovative approaches for the production of iron fortified noodles that are natural and economically feasible. The functional food was produced using different combinations . The investigated variables were the ratio of sorghum to white bean flour, pre-gelatinized flours (drum dried or extruded) and guar gum addition while the emulsifier added was kept co...

starch is a versatile and useful polymer having physicochemical properties that can be altered by chemicals or enzymatic modification and/or physical treatment. native starches possess many disadvantages that decrease their application and industrial use, but could be modified to obtain the desired properties to meet industrial needs for a wide range of starch applications. physically modified ...

Hydroxypropyl starch was synthesized by modified sago starch with hydroxypropylation reaction. Hydroxypropyl starch nanoparticles with mean particle sizes of 110 nm are obtained by controlled precipitation through the drop-wise addition of dissolved hydroxypropyl starch solution into excess absolute ethanol. Piperine was loaded onto hydroxypropyl starch nanoparticles and native starch nanoparti...

wheat starch is the most common type of starch in iran as well as many other parts of the world with enormous applications in food and non-food products. to improve its physicochemical properties or create new functionalities, starch can be modified by changing its molecular structure. amongst different methods for starch modification, physical methods have received more attention recently. pre...

Intrinsic factors affecting the rate of starch digestion in foods are the physical form of food, shape and crystal structure of the starch granule, recrystallization and retrogradation, amylose-lipid complexes, native α-amylase inhibitors and non-starch polysaccharides [1]. For nutritional purposes, starch is classified into three types based on these intrinsic factors: rapidly digestible starc...

A rice starch based film, reinforced with starch nanocrystals (prepared by submitting native granules of rice starch to acid hydrolysis at 40 oC) was prepared by casting film-solution on leveled trays. The influence of the content of starch nanocrystals (5 to 30%) on the mechanical, thermal and structural properties of rice starch films was investigated. The rice starch films showed an increase...