Introduction MRI techniques have recently demonstrated the ability to provide valuable anatomic imaging in the newborn brain, but additional metabolic markers would be important to provide improved assessments of neonatal brain injury. 3D point-resolved spectroscopic imaging (PRESS-MRSI) can provide accurate measurements of metabolite levels throughout the brain, but it is more complex than com...

BACKGROUND While cytochrome P4501A2 is the primary pathway for theophylline (aminophylline ethylenediamine) metabolism in adults, it is developmentally immature in the newborn. OBJECTIVE To report the developmental differences in theophylline toxicokinetics of neonates. DESIGN Case series. Three premature neonates received inadvertent intravenous overdoses of theophylline for apnea of prema...

To determine to what extent intravenous nutrition can reduce proteolysis in very immature and normal newborns, and to assess the capacity of preterm and normal newborns to convert phenylalanine to tyrosine, phenylalanine and leucine kinetics were measured under basal conditions and during parenteral nutrition in clinically stable, extremely premature (approximately 26 wk of gestation) infants a...

Introduction: Newborns with extreme prematurity are considered those who have a birth weight under 1000 grams. Morpho-functional plurivisceral imaturity lead to particular diseases, through frequency and gravity. Objectives: The authors aim to study a lot of newborns with extremely low birth weight and to determine the major complications specific for this category. Material and method: the stu...