OBJECTIVE To identify opportunities to reduce overuse of antibiotics for prevention of perinatal group B streptococcal (GBS) disease and management of preterm premature rupture of membranes (pPROM). METHODS An anonymous written questionnaire was sent to each of 1031 Fellows of the American College of Obstetricians and Gynecologists, and the responses were subjected to statistical analysis. ...

This study aims to explore potential clinical relevance of sHLA-G to premature rupture of membrane. 75 samples of pregnancy were enrolled, including patients with preterm premature rupture of membranes (PPROM), patients with term premature rupture of membranes (TPROM) and normal pregnancy women. Level of sHLA-G in multiple sites were examined with ELISA. Lymphocytes were isolated from periphera...

OBJECTIVE This study was undertaken to study the pharmacokinetics of intravenously administered amoxicillin in pregnant women with preterm premature rupture of the membranes (PPROM). STUDY DESIGN Healthy women with PPROM were recruited and treated with amoxicillin (2 g initially and 1 g subsequently). Blood samples were obtained from the opposite arm and concentrations determined with the use...

The common management in most centers in cases of multiple pregnancies with preterm premature rupture of membranes (PPROM) before 22 weeks of gestation is termination of the pregnancy or the expectant approach. Expectant management of previable PPROM in twin pregnancies results in an increased rate of fetal and neonatal morbidity and mortality of both twins. Selective fetocide of the twin with ...

INTRODUCTION Preterm premature rupture of membranes is a common complication of pregnancy associated with significant maternal, fetal and neonatal risks. An understanding of its magnitude and consequences is critical in providing appropriate intervention to prevent poor pregnancy outcomes. OBJECTIVE To describe maternal and perinatal outcomes of preterm premature rupture of membranes at Tikur...

Background: Premature rupture of the membrane (PROM) is a major cause of preterm birth, and the mechanisms still not fully defined. However, the mechanisms for PROM still not fully defined. This study investigated the roles of p38 in regulation the expression of MMP-9 and TIMP-1 in fetal membranes of patients with preterm premature rupture of membrane (PPROM) and full-term premature rupture of ...

The management of patients with premature rupture of membranes has changed markedly in the past several years. The basis for this is a combination of a better understanding of newborn physiology, improved neonatal care, refinements in antibiotic therapy, and the widespread use of maternal and fetal monitoring. The best outcome for both mother and infant undoubtedly reflects data based on a comb...

BACKGROUND Amniocentesis is the accepted mode of attaining amniotic fluid to perform tests for fetal lung maturity. The purpose of this study was to validate a non-invasive fetal lung maturity test by counting lamellar bodies from a vaginal pool among women with preterm premature rupture of membranes. METHODS In a prospective study, amniotic fluid specimens were collected from a vaginal pool ...

Objective Midtrimester preterm prelabor rupture of membranes (PPROM) has a high rate of neonatal mortality and morbidity. The aim of this study was to study outcomes of subsequent pregnancies after a pregnancy with PPROM before 27 weeks' gestation. Study Design Retrospective study of subsequent pregnancies of women who suffered PPROM before 27 weeks' gestation from 1994 to 2009. The main outcom...