The current study aimed to identify the determinants of objectively measured changes in sedentary time and sedentary fragmentation from age 9- to age 12 years. Data were collected as part of the Gateshead Millennium Birth Cohort study from September 2008 to August 2009 and from January 2012 to November 2012. Participants were 9.3 (± 0.4) years at baseline (n = 508) and 12.5 (± 0.3) years at fol...

The analysis of post-translational modifications (PTMs) by proteomics is regarded as a technically challenging undertaking. While in recent years approaches to examine and quantify protein phosphorylation have greatly improved, the analysis of many protein modifications, such as glycosylation, are still regarded as problematic. Limitations in the standard proteomics workflow, such as use of sub...

The in vitro effects of derivatives of cyclic adenosine 3',5'-monophosphate (cAMP) and glycosaminoglycans (GAGs) on the spontaneous induction of fragmentation of cultured porcine oocytes were examined. Oocytes cultured for 72 h or longer undergo spontaneous fragmentation, and the percent of fragmented oocytes increased thereafter. The fragmented oocytes consisted of several "blastomeres" showin...

(2013) A new methodology for measuring land fragmentation. Abstract The presence of land fragmentation implies that the existing land tenure structure is defective. It is a major problem in many regions because it restricts agricultural development and reduces the opportunities for sustainable rural development. Whilst policies to counter land fragmentation require reliable measurement indices,...

Understanding the consequences of fragmentation of coastal habitats is an important topic of discussion in marine ecology. Research on the effects of fragmentation has revealed complex and context-dependent biotic responses, which prevent generalizations across different habitats or study organisms. The effects of fragmentation in marine environments have been rarely investigated across heterog...

OBJECTIVES This study was designed to assess the feasibility, efficacy and safety of mechanical fragmentation of pulmonary emboli using a new rotational pigtail catheter system. BACKGROUND Acute massive pulmonary embolism associated with right ventricular dysfunction is frequently lethal, despite high-dose thrombolytic therapy. Adjunctive catheter fragmentation may prevent a fatal outcome. ...

Abstract Orangutans are an endemic to Indonesia and Malaysia with almost extinct critically endangered status only found on the islands of Sumatra Kalimantan/Borneo. Orangutan extinction is mainly threat by habitat loss fragmentation as well low reproduction rates. Habitat fragmentation, along loss, should be clearly considered when assessing implications landscape change for population extinct...

A new computational model for brittle fracture and fragmentation has been developed based on finite element analysis of non-linear elasticity equations. The proposed model propagates the cracks by splitting the mesh nodes alongside the most over-strained edges based on the principal direction of strain tensor. To prevent elements from overlapping and folding under large deformations, robust geo...

We introduce a coevolution voter model in a multilayer by coupling a fraction of nodes across two network layers (the degree of multiplexing) and allowing each layer to evolve according to its own topological temporal scale. When these time scales are the same, the time evolution equations can be mapped to a coevolution voter model in a single layer with an effective average degree. Thus the dy...

The second paper of this series adopts particle modeling (PM) to simulation of dynamic fracture phenomena in homogeneous and heterogeneous materials, such as encountered in comminution and blasting processes in mining industry. As the basis for such simulations, we first develop a new method to prevent particles from topologically interpenetrating themselves within the material domain, when act...