BACKGROUND The cosyntropin stimulation test is the initial endocrine evaluation of suspected primary or secondary adrenal insufficiency. PURPOSE To critically review the utility of the cosyntropin stimulation test for evaluating adrenal insufficiency. DATA SOURCES The MEDLINE database was searched from 1966 to 2002 for all English-language papers related to the diagnosis of adrenal insuffic...

Introduction and purpose
 Addison's syndrome is defined as primary adrenal insufficiency, the symptoms of which result from hormonal deficiencies: glucocorticosteroids, mineralocorticosteroids androgens. Currently, autoimmunity considered most common cause Syndrome. Antibodies are often directed against enzymes 21-hydroxylase 17-hydroxylase involved in steroidogenesis.
 The aim study ...

Adrenal insufficiency is the clinical manifestation of deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. It is a life-threatening disorder that can result from primary adrenal failure or secondary adrenal disease due to impairment of the hypothalamic-pituitary axis. Prompt diagnosis and management are essential. The c...

Adrenal insufficiency is relatively rare in childhood and adolescence. Signs and symptoms may be nonspecific; therefore, the diagnosis may not be suspected early in the course. If unrecognized, adrenal insufficiency may present with life-threatening cardiovascular collapse. Adrenal crisis continues to occur in children with known primary or secondary adrenal insufficiency during intercurrent il...

Patients with acute adrenal insufficiency may have musculoskeletal symptoms including flexion contractures, myopathy and hyperkalaemic neuromyopathy. However, the association between rhabdomyolysis and acute adrenal insufficiency is extremely rare and has only been reported infrequently in the literature. Hyponatraemia is often present in association with acute adrenal insufficiency complicated...

Background/ObjectiveInfiltrative fungal infections are an unusual cause of primary adrenal insufficiency (AI). Our objective is to present long term follow-up a patient with AI due crytpococcal adrenalitis.Case ReportA 47 year old woman presented in January 2004 50 lb. weight loss, nausea, emesis, and headache diplopia. During the 6 months prior her presentation had multiple admissions for eval...

Primary adrenal insufficiency is defined by the impaired synthesis of adrenocortical hormones due to an intrinsic disease of the adrenal cortex. Determining its etiology is crucial to allow adequate long-term management and genetic counseling. We report the case of a male adolescent that presented in the neonatal period with adrenal crisis and received replacement therapy for primary adrenal in...