Malignant lymphomas that secondarily involve the skin are relatively common and may be difficult to distinguish from primary skin lymphomas. While the morphologic features of primary and secondary lymphomas of the skin are often very similar, the clinical behavior of primary and secondary disease is often dramatically different. Although large series of secondary cutaneous lymphomas are uncommo...

We describe a patient with primary cutaneous small-tomedium--sized CD4+ T-cell lymphoma, according to the most recent World Health Organization (WHO) classification of cutaneous lymphomas. This lymphoma, previously known as primary cutaneous small-to-medium-sized pleomorphic CD4+ T-cell lymphoma, has a low incidence and good prognosis. The interest in the case presented in this report derives f...

A proangiogenic micromilieu is associated with a worse prognosis in systemic lymphoma. Hence, targeting the tumour microenvironment and its vasculature has evolved as a promising novel treatment strategy. The role of tumour neoangiogenesis in cutaneous B-cell lymphoma, however, has not yet been elucidated. Therefore, we examined the expression of vascular endothelial growth factor (VEGF) and it...

CNS: central nervous system CSF: cerebrospinal fluid PCMZL: primary cutaneous marginal zone lymphoma WBC: white blood cells BACKGROUND Primary cutaneous marginal zone lymphoma (PCMZL) is an indolent B-cell lymphoma, typically characterized by frequent cutaneous recurrences and rare systemic involvement. Lymph nodes, bone, and bone marrow are commonly affected sites in rare cases of extracutaneo...

Primary cutaneous lymphomas, which are diagnosed with only skin involvement, can be of B or T cell origin. Due to their varied origin as well diverse presentations, these groups have been divided further into more descriptive and representative groups. The subtypes primary marginal zone lymphoma (PCMZL), follicle center (PCFCL), diffuse large lymphoma, leg type (PCDLBCL-LT) intravascular B-cell...

Lymphoma is a cancer of the lymphocytes which leads to solid tumors in the lymphoid organs involving lymph nodes, spleen, liver, bone marrow and skin. Primary cutaneous lymphoma, a rare subtype of non-Hodgkin's lymphoma, can be classified as cutaneous T-cell or cutaneous B-cell lymphoma. These tumors are mostly T-cell origin and mainly locate on trunk, extremities and scalp or forehead. In this...