We report a new strategy for designing a signal off-to-on-type (19)F MRI chemical probe that operates in biological environments. The present strategy is based on the control of adherence of a (19)F MRI chemical probe to certain blood proteins, accompanied by a change in transverse relaxation time of (19)F nuclei.

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Probe specificity plays a central role in designing accurate microarray hybridization assays. Current literature on specific probe design studies algorithmic approaches and their relationship with hybridization thermodynamics. In this work we address probe specificity properties under a stochastic model assumption and compare the results to actual behavior in genomic data. We develop efficient ...

1 Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea 2 Medigenes Co. Ltd., 713 Suseo-dong, Gangnam-Gu, Seoul 135-539, Republic of Korea 3 Department of Biosystems, Korea Advanced Institute of Science and Technology, 3731 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of ...

BACKGROUND Francisella tularensis (F. tularensis) is the etiological microorganism for tularemia. There are different forms of tularemia such as respiratory tularemia. Respiratory tularemia is the most severe form of tularemia with a high rate of mortality; if not treated. Therefore, traditional microbiological tools and Polymerase Chain Reaction (PCR) are not useful for a rapid, reliable, accu...

INTRODUCTION Urinary tract infections are predominant diseases which may be caused by different pathogenic microorganisms, particularly Escherichia coli (E.coli). DNA microarray technology is an accurate, rapid, sensitive, and specific diagnostic tool which may lead to definite diagnosis and treatment of several infectious diseases. DNA microarray is a multi-process method in which probe design...

Scanning probe microscopes are notoriously susceptible to disturbances, or mechanical noise, from the surrounding environment that couple to the probe–sample interaction. These disturbances include vibrations of mechanical components, piezo drift, and thermal expansion. Disturbance effects can be substantially reduced by designing a rigid microscope, incorporating effective vibration isolation,...