A rapid, sensitive and reproducible HPLC method using amperometric detector was developed and validated for the analysis of clarithromycin in human plasma. The separation was achieved on a monolithic silica column (MZ- C8 125×4.0 mm) using acetonitrile- methanol-potassium dihydrogen phosphate buffer (40:6:54,v/v), with pH of 7.5, as the mobile phase at a flow rate of 1.5 mL/min. The assay enabl...

stability of foundations near slopes is one of the important and complicated problems in geotechnical engineering, which has been investigated by various methods such as limit equilibrium, limit analysis, slip-line, finite element and discrete element. the complexity of this problem is resulted from the combination of two probable failures: foundation failure and overall slope failure. the curr...

The development of sound Analytical method(s) is of supreme importance during the process of drug discovery, release to market and development, culminating in a marketing approval. The objective of this paper is to review the method development, optimize and validation of the method for the drug product from the developmental stage of the formulation to commercial batch of the product. Method d...

A rapid, sensitive and reproducible HPLC method using amperometric detector was developed and validated for the analysis of clarithromycin in human plasma. The separation was achieved on a monolithic silica column (MZ- C8 125×4.0 mm) using acetonitrile- methanol-potassium dihydrogen phosphate buffer (40:6:54,v/v), with pH of 7.5, as the mobile phase at a flow rate of 1.5 mL/min. The assay enabl...

In this work, we calculate the limit distribution of the total cost incurred by splitting a tree selected at random from the set of all finite free trees. This total cost is considered to be an additive functional induced by a toll equal to the square of the size of tree. The main tools used are the recent results connecting the asymptotics of generating functions with the asymptotics of...

Adsorption thin layer chromatography (NP-TLC) with densitometry has been established for the identification and the quantification of acetaminophen in three leading commercial products of pharmaceutical tablets coded as brand: P1 (Product no. 1), P2 (Product no. 2), and P3 (Product no. 3). Applied chromatographic conditions have separated acetaminophen from its related substances, namely, 4-ami...

a catalytic-kinetic method for the determination of selenium is proposed. alizarin navy blue is reduced by sodium sulfide to from a colorless product. the reaction is accelerated by trace amounts of se (iv), and can be followed by measuring the decrease in absorbance of the dye at 620nm and 30 °c by the fixed time method. selenium can be determined in the range of 0.004 — 0.12 1.1g.m1-1 . ...

ultimate limits of an open pit, which define its size and shape at the end of the mine’s life, is the pit with the highest profit value. a number of algorithms such as floating or moving cone method, floating cone method ii and the corrected forms of this method, the korobov algorithm and the corrected form of this method, dynamic programming and the lerchs and grossmann algorithm based on grap...