background: luteal phase support is mandatory in art (assisted reproductive technologies) for optimizing outcome, so the luteal phase is supported with either progesterone, addition of estradiol to progesterone, hcg or gonadotropin releasing hormone (gnrh) agonists. supplementation of luteal phase with progesterone is prescribed for women undergoing routine ivf treatment. objective: to compare ...

OBJECTIVE The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. STUDY DESIGN A randomized, double-blind, placebo-controlled study included 142 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administered daily by vaginal suppository and all patients underwent uterine contracti...

BACKGROUND Luteal phase support is mandatory in assisted reproductive technologies (ART) for optimizing outcome, so the luteal phase is supported with either progesterone, addition of estradiol to progesterone, hCG or gonadotropin releasing hormone (GnRH) agonists. Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment. OBJECTIVE To compare ...

BACKGROUND Preterm birth is the major cause of neonatal mortality and morbidity. OBJECTIVE The aim of this study was to evaluate the effect of prophylactic vaginal progesterone on decreasing preterm birth rate and neonatal complications in a high-risk population. MATERIALS AND METHODS A randomized, double-blind, placebo-controlled study was performed on 100 high-risk singleton pregnancies. ...

Preterm birth (PTB) is one of the most common complications during pregnancy and it primarily accounts for neonatal mortality and numerous morbidities including long-term sequelae including cerebral palsy and developmental disability. The most effective treatment of PTB is prediction and prevention of its risks. Risk factors of PTB include history of PTB, short cervical length (CL), multiple pr...

The aim of this study was to compare the effects of oral and suppository of Progesterone in pregnant women lower than 12th weeks of gestation with threatened abortion to prevent miscarriage. This random clinical trial study was conducted on 200 pregnant women with threatened abortion and gestational age ≤ 12 weeks who were referred to Kosar obstetrics and gynecology clinic in Shahid Motahari ho...

background: preterm birth is the major cause of neonatal mortality and morbidity. objective: the aim of this study was to evaluate the effect of prophylactic vaginal progesterone on decreasing preterm birth rate and neonatal complications in a high-risk population. materials and methods: a randomized, double-blind, placebo-controlled study was performed on 100 high-risk singleton pregnancies. v...

Main results 10 studies (531 women) of 14 published trials testing the efficacy of progesterone met the selection criteria. 1 study used both suppositories and oral preparations and was treated as 2 studies in the meta-analysis. The pooled results for 8 studies on suppositories and 3 studies on oral drugs showed a small benefit for progesterone in the reduction of symptoms (table). When results...

To achieve successful delivery of drug locally as well as systematically rectal route has proved its potential. The main objective of this research work was to evaluate the in vivo performance of paracetamol Suppocire CP suppository. Initially, suppositories were prepared, evaluated for their physicochemical parameters and in vitro drug release. An in vivo investigation of paracetamol availabil...