Cancer prognosis prediction is typically carried out without integrating scientific knowledge available on genomic pathways, the effect of drugs on cell dynamics, or modeling mutations in the population. Recent work addresses some of these problems by formulating an uncertainty class of Boolean regulatory models for abnormal gene regulation, assigning prognosis scores to each network based on i...

human epidermal growth factor receptor-2 (her-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. about 280 articles were reviewed and 115 were referred in this review article on her-2. her-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. overexpression results in aggressive behavior, ...

background & objectives: colon cancer is currently of high incidence and mortality rate. identifying the factors influencing its prognosis can be very beneficial to its clinical treatment. recent studies have shown that lymph nodes ratio can be considered as an important prognostic factor. the aim of the present study is to investigate the effect of this factor on the prognosis of the patie...

Background:Brain and Acute Leukemia Cytoplasmic (BAALC) is a gene which its expression is confined to progenitor cells; therefore, no expression has been illustrated in mature cells of bone marrow or white blood cells (WBC).  In addition, high BAALC expression is associated with poor prognosis in Acute Myeloid Leukemia (AML) individuals and is considered as an important risk factor in Cyto...

OBJECTIVE To demonstrate an association between thrombocytopenia and platelet behavior in predicting mortality in septic patients. METHODS Patients with criteria for sepsis at admission or at any time during hospitalization were selected; patients hospitalized for less than 24 hours were excluded. Thrombocytopenia was defined as a platelet count lower than 150.000/mm³, and recovery was define...

background and objectives: gliomas are the most prevalent primary brain tumors. the purpose of this retrospective cohort study was evaluation of clinical trend and prognosis of patients with brain glioma and effective factors in prognosis. materials and methods: hundred and forty-five patients with supratentorial brain glioma, treated in shahid mostafa khomeini & hazrat-e-rasool hospitals i...

OBJECTIVES The purpose of this article is to evaluate factors influencing prognosis of arthrocentesis in patients with temporomandibular joint (TMJ) disorder. MATERIALS AND METHODS The subjects included 145 patients treated with arthrocentesis at the Dental Center of Ajou University Hospital from 2011 to 2013 for the purpose of recovering mouth opening limitation (MOL) and pain relief. Progno...