a 63-year-old woman suffering from progressive systemic sclerosis for about 20 years disclosed symptoms of liver disease within the last three years. diagnosis of biliary cirrhosis was established on the basis of clinical picture, pathological examination of the hepatic tissue sample, immunological tests, and x-ray studies. association of systemic sclerosis with primary biliary cirrhosis is bri...

conclusions the individuals should have multidisciplinary approach for the variety of disorders to maintain the appropriate treatment for a better appearance of the patients. case presentation we describe a patient with progressive hemifacial atrophy at right facial side who developed granulomatous uveitis and periferic retinal vasculitis in his left eye. we started topical and systemic steroid...

multiple sclerosis is a cns autoimmune disease configured by demyelination, inflammation, and degeneration of axons. this disease inflict great harms to patients. the most common problem is inability to control musculoskeletal system and decrease in mobility. these consequences could vary from patients to patients. about 10-15% of all ms patients develop primary progressive ms (ppms). despite t...

diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. the potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. obesity and alignment especially varus malalignment are recognized factors of a progressive disease. both nonpharmalogical as well as pharmacological modalities of treat...

the present paper investigates the advantages of a new class of composite grid structures over conventional grids. thus far, a known grid structure such as orthogrid or isogrid has been used as an orthotropic layer with at most in-plane anisotropy. the present laminated grid is composed of various numbers of thin composite grid layers. the stiffness of the structure can be adjusted by choosing ...

Background and aim: Vitiligo is an acquired idiopathic hypomelanotic disease. The purpose of this study was to review clinical characteristics of vitiligo and their significance in the progression of vitiligo.Materials and methods: Eight hundreds and sixteen cases of vitiligo were studied from February 2005 to October 2006. All of the patients were referred to dermatolo...

In this issue of Clinical Cancer Research , Desai et al. (1) present evidence that new modules appearing in preexisting lesions can represent clonally resistant populations. Imatinib mesylate, the prototypic oral tyrosine kinase inhibitor that has activity against ABL, KIT, and platelet-derived growth factor receptor kinases arguably represents the most important oncologic advance of the past 3...