vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. interleukin 17 (il-17a) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (cox2). the aim of this study was to investigate the gene expression of il-17 and cox2 in peripheral blood leukocy...

BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) is associated with evidence of systemic oxidative stress, activation of circulating inflammatory cells and increased plasma level of proinflamatory cytokines which include C-reactive protein (CRP). CRP is one biomarker of extrapulmonary or systemic consequences of COPD that can be detected. AIM The aim of this research is to determine wh...

Tumor Necrosis Factor alpha (TNF-α) is a proinflamatory cytokine, closely associated with insulin resistance and related diseases such as type II ketosis and fatty liver of cows. Aim of the presented study was to investigate circulating levels of TNF-α after vaccinating dry cattle with inactive rotavirus, coronavirus and E.coli combined vaccine. 14 cattle were randomly assigned to two groups; v...

Two-component mRNA-based vaccine (RNActive) combines high antigen expression with strong immune stimulation. We have previously shown that intradermal administration of RNActive vaccines induced balanced, potent and long-lasting immune responses in both mice and humans. Here, we characterized in detail early events after vaccine injection to better understand the self-adjuvant capacity of mRNA-...

antifibrotic therapies should preferentially be targeted to the activated hepatic mesenchymal cells. those cells resemble wound healing myofibroblasts and synthesize an excess of extracellular matrix (ecm) proteins. they derive from quiescent hepatic stellate cells (hsc) and portal/perivascular (myo-) fibroblasts (mf). whereas various agents have been shown to inhibit hsc/mf proliferation and c...

background depression and sleep disorders are more prevalent among rotational shift workers than regular day workers. people with sleep disorders have higher inflammatory and pre-inflammatory cytokines than those in the control group. objectives the present study was conducted to investigate serum level of high sensitivity c-reactive protein (hscrp), interleukin-6 (il-6) and cortisol among depr...

background: cutaneous leishmaniasis is an endemic disease in many regions of iran, including the city of mashhad. in recent years, some cases have not responded to glucantime, the usual treatment for this disease. the cellular immune response caused by t-helper type 1 (th1) cells has an important role in protection against leishmaniasis, and activation of the t-helper type 2 (th2) response caus...

background there is a strong relationship between physical inactivity and low-grade inflammation and its adverse health outcomes, particularly cardiovascular disease. the level of anti-inflammatory and pro-inflammatory cytokines may be changed by exercise. objectives the aim of the present study was to determine the response of certain inflammatory biomarkers to exercise with differences in max...

chronic idiopathic urticaria is defined as recurrent hives occurring for at least 6 weeks. in  the  majority of  cases, there  is no  identifiable underlying etiology despite  extensive evaluation. a subset of these patients is classified as having autoimmune urticaria defined by the presence of a functional igg antibody to the α subunit of the high-affinity ige receptor (fceria) or to ige. the...