il-1β and il-17a are two cytokines with strong proinflammatory activities and are now known to be involved in a number of chronic inflammatory disorders. high-mobility group box 1 (hmgb1) is a nuclear protein regulating the expression of these proinflammatory cytokines. the nlrp3 inflammasome promotes the maturation of the il-1β and its activation has been shown as a critical mechanism in the p...

introduction: based on human studies, inequality and social injustice have adverse effects on the individual and community health. in this study, the effects of food intake inequality and social status changes on pain perception and immunological factors were investigated in balb/c mice. methods: the present study was conducted by implementing different social stresses including food deprivatio...

The lipoprotein(a) [Lp(a)] particle may impact cardiovascular risk through antifibrinolytic, proinflammatory, and proatherogenic mechanisms, the apolipoprotein(a), oxidized phospholipids (OxPLs), LDL components, respectively. Because it is difficult to separate these effects out in vivo, they probably contribute various but different extents all age groups. However, proposed that specific prope...

One of the most important problems in neuroscience researches is the understanding what is the communication between the immune system and central nervous system. Proinflammatory factors play an important role in this communication. The dysregulation of proinflammatory factors such as cytokines and chemokines is a central feature in the development of neuroinflammation.one of the important&nbsp...

introduction: following a traumatic brain injury (tbi), the excessive release of proinflammatory cytokines is major cause of cerebral edema that can cause permanent neuronal loss. this study examined the changes in brain concentrations of proinflammatory cytokines il-1, il-6, tnf-α and tgf- after different doses of estrogen or progesterone treatment in brain-injured rats at 6 and 24 h post-in...

BCG vaccination significantly diminished proinflammatory responses in elderly individuals COVID-19 hot spots.

conclusions regular resistance training and prostatic massage can improve proinflammatory markers and psa levels in men with pc. results in the resistance training group, il-10 levels significantly increased after four (p = 0.055) and eight weeks (p = 0.000). four and eight weeks of resistance training showed a significant reduction in psa, crp, il-6, and tnf-α levels (p < 0.05). patients of ma...