LESSONS LEARNED Despite evidence for a role for prolactin signaling in breast and prostate tumorigenesis, a prolactin receptor-binding monoclonal antibody has not produced clinical efficacy.Increased serum prolactin levels may be a biomarker for prolactin receptor inhibition.Results from the pharmacokinetic and pharmacodynamics (PD) studies suggest that inappropriately long dosing intervals and...

perimental animals were Wistar female rats maintained under controlled lighting. LH, FSH and prolactin in serum and pituitary were determined by means of double antibody radioimmunoassay. The results were as follows:1) Electrical stimulation (100Hz, 0.1ms and 100ƒÊA) of the PVA through chronically implanted electrode at 12:00 on the day of proestrus increased the serum concentrations of LH and ...

A double-antibody radioimmunoassay technique has been used to investigate the serum prolactin (hPRL) level in Malay females from premenarche to the postmenopause. The results showed that the hPRL level (mena ± SEM) in the premenarchal, postmenarchal and late pubertal/reproductive subjects were 23.6 ± 2.3,19.1 ± 2.0 and 22.7 ± 1.9 ng] ml respectively. In premenopausal women, hPRL level (11.8 ± 2...

The recent report, “Serum prolactin level in psoriasis”, is very interesting 1. Ghiasi et al. concluded that “it seems that while intracutaneous prolactin may contribute to the pathogenesis of psoriasis, the probable role of pituitary-produced circulating prolactin in the disease process needs further investigation .” There are some concerns on this report. First, although Ghiasi et al. have st...

AIMS Prolactin plays an important role in the proliferation and differentiation of normal breast epithelium, and possibly in the development of breast carcinoma. The effects of prolactin are mediated by its receptor; thus, alteration in the expression of this receptor could be important in studying the biology of breast cancer. This investigation was aimed at comparing the expression of prolact...

We describe an immunofluorometric assay for prolactin based on lanthanide labelingof a monoclonalantibody and measuring time-resolved fluorescence. In this “sandwich”type assay, the label (Eu3) was bound to the second antibody by means of a simple, rapid method involving the anhydride of diethylenetriaminepentaacetic acid. To measure the photoluminescence of europium (or other lanthanides), we ...

background patients with intellectual disabilities may be treated with antipsychotic medications for a variety of diagnoses. use of this category of medication can increase prolactin levels and place the patient at risk for sexual dysfunction and lower bone mineral density. the proposed mechanism of action is affinity for the dopamine receptor. use of bromocriptine, a dopamine receptor antagoni...

background: serum prolactin level has been used as an alternative determinant to help differentiate epileptic from non-epileptic seizures. we aimed to analyze the association between serum prolactin concentration and epileptic seizure versus febrile seizure as well as seizure duration, single versus multiple seizure attacks and time lapse between seizure onset and blood sampling.   methods: sev...