OBJECTIVE To compare the effect of intramuscular olanzapine with intramuscular haloperidol plus promethazine on rapid tranquillisation of agitated or violent people with mental illness. DESIGN Pragmatic, allocation concealed, randomised controlled trial. SETTING Emergency services of a general hospital psychiatry department in Vellore, south India. PARTICIPANTS 300 adults with agitated or...

abstract introduction: the aim of this study was to compare the therapeutic and adverse effects of haloperidol to the combination of haloperidol and promethazine (antipsychotic + antihistamine) for controlling patients with aggressive or violent behavior referred to psychiatric emergency rooms. methods: using a double-blind randomized controlled trial, 100 psychiatric patients admitted to emerg...

The metabolic effects of intraperitoneal administration of promethazine on normoxic, hypoxemic and hypoxemic-oligemic rat brain were assessed by measurement of the cerebral contents of energy phosphates, and selected glycolytic-citric acid cycle intermediates. In normoxic brain promethazine (25-100 mg/kg-1) was associated with unaltered adenylates, increased glucose and aspartate and decreased ...

PURPOSE Intramuscular (i.m.) injections of promethazine in 25 mg or 50 mg dosages are commonly used to treat space motion sickness in astronauts. The present study examined the effects of i.m. injections of promethazine on performance, mood states, and motion sickness in humans. METHODS Subjects were 12 men, mean age 36 + 3.1, who participated in 1 training day and 3 treatment conditions: a 2...

The voltammetric study of promethazine on multi-walled carbon nanotubes (MWNTs) coated gold electrode (MWNTs/Au) has been carried out. Promethazine can cause a sensitive anodic peak on it. In pH=4.0 phosphate buffer solution, the peak potential is 0.66 V (vs. SCE). The electrode process is adsorption-controlled, the adsorption amount is about 9.9×10 mol cm (for 1.0×10 M promethazine), and the e...

BACKGROUND AND OBJECTIVES Histamine receptors mediate nociceptive pathways, especially in the central nervous system. Some studies have demonstrated the analgesic effects of histamine receptor antagonists in the peripheral nervous system. It is not clear whether the local analgesic effect is class-specific or drug-specific. METHODS To answer this question, we used three different H1 receptor ...

BACKGROUND Postoperative nausea and vomiting is a high unpleasant symptom in surgical procedures. This study compares the effectiveness of midazolam with promethazine as multipurpose drug in postoperative nausea and vomiting as a preoperative and anesthetic medication after appendectomy. Methods : This randomized, double - blind clinical trial study was performed in patients who underwent appen...

Postoperative nausea and vomiting frequently complicate outpatient anesthesia and surgery. The duration of treatment for this complication must occasionally extend beyond discharge from the hospital. In this study, we evaluated the commonly used anti-emetic promethazine for its efficacy in the post-discharge period. Adult outpatient surgical patients who had excessive postoperative nausea and v...

Intramuscular (i.m.) injections of promethazine in 25 mg or 50 mg dosages are commonly used to treat space motion sickness in astronauts. The present study examined the effects of i.m. injections of promethazine on neuropsychological performance, mood states, and motion sickness tolerance in humans. Twelve men, mean age 36 _+3.1, participated in one training (no injections) and three treatment ...

Evidence is presented from more than 300 subjects to show that promethazine potentiates the action of six different narcotics (morphine, pethidine, oxymorphone, hydromorphone, fentanyl and pentazocine). In each instance there was prolongation rather than deepening of the narcotic action. Such an effect is consistent with the known membrane-stabilizing action of promethazine and is likely to occ...