CONTEXT Proniosomes offer a versatile vesicle drug delivery concept with potential for delivery of drugs via transdermal route. OBJECTIVES To develop proniosomal gel using cremophor RH 40 as non-ionic surfactant containing the antihypertensive drug lacidipine for transdermal delivery so as to avoid its extensive first pass metabolism and to improve its permeation through the skin. MATERIALS...

Vesicular approaches are novel techniques for transporting the drug that reinforces availability of drugs and gives an action a prolonged time. Besides, it has definite advantages over traditional delivery systems. Liposomes niosomes comprising vesicles demonstrate stability issues such as aggregation, leakage, fusion sedimentation due to aqueous nature system. The provesicular system developed...

The aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. Three independent variables selected were molar ratio of drug to lipid (X1), surfactant loading (X2) and volume of hydration (X3). Based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

The aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. Three independent variables selected were molar ratio of drug to lipid (X1), surfactant loading (X2) and volume of hydration (X3). Based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

Diabetes Mellitus (DM) has emerged as an epidemic that affected millions of people globally in the last few decades. Conventional antidiabetic dosage forms have a lot problems necessitate searching for novel drug delivery systems to overcome these drawbacks. Niosomes and proniosomes been used carry wide variety drugs achieving controlled sustained release, which improves patient compliance. Thi...