2-Propylthiouracil has been reported as replacing glutathione as a substrate for the glutathione transferases of rat liver. This observation has been examined with several homogeneous glutathione transferases that were prepared from human and rat liver by different methods in three laboratories. No evidence was obtained for 2-propylthiouracil as a substrate for glutathione transferase in the se...

Hyperthyroidism is more common in women and the sensitivity of thyroid function changes during pregnancy. Excess levels hormones thioamides have a major impact on maternal fetal outcomes. Our aim was to perform an extensive literature review provide relevant details concerning analytical clinical aspects potential effects two main drugs used (methimazole propylthiouracil) newborns. A thorough c...

This study was conducted to determine the relationship between 6-n-propylthiouracil sensitivity and taste characteristics in female students at Nara Women's University. Participants (n=135) were screened for 6-npropylthiouracil sensitivity using a taste test with 0.56 mM 6-n-propylthiouracil solution, and the sensitivity was confirmed by an assay for the bitter-taste receptor gene, TAS2R38. Bas...

PURPOSE Propylthiouracil is one of the thionamides used in the treatment of Graves' disease. The drug has serious side effects and long-term treatment might be needed to achieve remission. We designed this study to evaluate the clinical and thyroid Doppler characteristics that might predict time to remission and treatment failure in propylthiouracil treated Graves' patients. METHODS 26 patien...

Recent changes in New Zealand have altered the availability of propylthiouracil. It is no longer a ‘funded’ medication but is only available via an ‘Exceptional Circumstances’ application to the Pharmaceutical Management Agency (PHARMAC). Because of this a number of patients in our practice were changed from propylthiouracil to carbimazole. We report a patient who developed agranulocytosis foll...

Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmon...

Carbimazole is a common treatment for hyperthyroidism in the UK. Its main side effects include a rash, agranulocytosis and rarely a lupus-like syndrome. Although vasculitis associated with antineutrophil anticytoplasmic antibodies (ANCA) has been reported on several occasions following treatment with propylthiouracil, vasculitis with carbimazole appears to be less common. We report a case of le...