background: prostate cancer (pca) is an important health problem in the aging male population in the world. it is the third most common cancer in the world. despite of its importance, relatively little is known about its etiology. sexually transmitted infections (sti) and urogenital pathogens such as mycoplasma and ureaplasma, have been proposed as a risk factor for prostate cancer development....

perforin(p) is the primary mediator of short term cytotoxicity, it is accumulated in response to proinflammatory  cytokines and stored in t lymphocyte , nk cells and nkt cells are released upon activation. perforin is a prototypical cytotoxic molecule involved in cell mediated immunity against various pathogens , alloantigens and particularly different tumors.the purpose of this study was to de...

background : a single nucleotide variation within  atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...

anti-androgens are an assorted group of drugs and compounds that reduce the levels or activity of androgen hormones within the human body. disease states in which this is relevant include polycystic ovarian syndrome, hirsutism, acne, benign prostatic hyperplasia, and endocrine related cancers such as carcinoma of the prostate. we provide an overview and discussion of the use of anti-androgen me...

Prostatic intra-epithelial neoplasia (PIN) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. In this study, we applied the PIN grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of...

The metabolism of plasticizing phthalates may correlate with an increased risk benign prostatic hyperplasia in humans. Diethylphthalate (DEHP) and its metabolites interfere sex hormone function, causing inflammation oxidative stress at low doses. effects contribute to the development prostate hyperplasia.

there are emerging data on novel tumor markers such as matrix metalloproteinase-2 (mmp-2 or gelatinase-a), which play a key role in tissue invasion and metastasis. we designed an investigation to assess the usefulness of mmp-2 activity as compared to prostate specific antigen (psa) in cancer staging process. we have analyzed the circulating form of mmp-2 in serum samples of patients suffering f...

introduction bladder diverticulum is a result of bladder mucosa and submucosa herniation through the muscularis propria of bladder wall. bladder diverticula are mostly seen in the elderly men in association with benign prostatic hyperplasia (bph). case presentation a 74-year-old man presented with complaints of vague epigastric discomfort, dyspepsia, and mild lower urinary tract symptoms. an ul...

Objective: To evaluate the correlation of International Prostatic Symptom Score with Prostate Volume Benign Hyperplasia patients. Study Design: A Cross- out sectional study was done. Qualitative variables measured by Chi square test and quantitative ANOVA. Pearson & multinominal regression were applied. P value considered significant at <0.05. It conducted in a tertiary care hospital, Zi...

prostatic intra-epithelial neoplasia (pin) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. in this study, we applied the pin grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of pro...