infection with hepatitis c virus (hcv) is a worldwide problem. among hcv proteins, core antigen (ag), besides its importance for diagnostic application is a prime candidate for component of a vaccine. herein, we report results of studies on production of the hydrophilic domain of core ag (2-122) in native conformation by an arabinose induction system in e.coli and the primary characterization o...

The determination of gyration radius is a strong research for configuration of a Macromolecule. Italso reflects molecular compactness shape. In this work, to characterize the behavior of theprotein, we observe quantities such as the radius of gyration and the average energy. We studiedthe changes of these factors as a function of temperature for Acetylcholine receptor protein in gasphase with n...

Turmeric (Curcuma longa L.) is an herbal plant that has many benefits as a treatment, including during the COVID-19 pandemic, one of mechanisms inhibition SARS CoV-2 to inhibit attachment ACE2 with Spike. The binding spike protein receptor will produce conformational changes in S protein, this study was conducted using silico method (computational analysis) which aims determine potential effica...

Combining SERS and statistical analysis, we demonstrated that an aptamer is a flexible molecule blocked in specific conformation to capture its analyte provided evidence for the dynamics of aptamer/protein interaction.

Proteinopathy is characterized by the accumulation of aggregates a specific protein in target organ, tissue, or cell. The aggregation same can cause different pathologies as single adopt various amyloidogenic, disease-specific conformations. conformation governs interaction amyloid with other proteins that are prone to misfolding and, thus, determines spectrum concomitant pathologies. In this r...

estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. a...

Parkinson?¦s disease (PD) is a devastating and an intricate complex neurological disorder that results from the progressive degeneration of nerve cells in Substantia nigra that controls movement. The pathological hallmark of PD is the formation of insoluble protein aggregates known as lewey bodies. Alpha-synuclein is the major constituent of these fibrillar structures. Alpha-synuclein a 140 ami...