Phosphorylation is a posttranslational modification of proteins that regulates many biological functions, such as development, morphogenesis, gene expression, metabolism and neuronal activity. Dysregulation phosphorylation causes diseases including cancer Alzheimer’s disease. Then, lot research has been performed to reveal the molecular mechanism phosphorylation; identification site(s), protein...

Background: Oleuropein, the main constituent of olive fruit and leaves, has been reported to protect against insulin resistance and diabetes. While many experimental investigations have examined the mechanisms by which oleuropein improves insulin resistance and diabetes, much of these investigations have been carried out in either muscle cell lines or in vivo models two scenarios with many draw...

Phosphorylation has been hypothesized to alter the ability of tau protein bind with microtubules (MT), and pathological level phosphorylation can incorporate formation Paired Helical Filaments (PHF) in affected tau. Study effect on different domains (projection domain, microtubule binding sites N-terminus tail) is important obtain insight about neuropathology. In an earlier study, we have alrea...

recognition of the molecular mechanisms of camp action against dna damage-induced apoptosis can be useful to improve the efficacy of dna damaging therapeutic agents. considering the critical role of bcl-2-associated death promoter (bad) and p53 proteins in dna damage -induced apoptosis, the aim of this study was to assess the effect of camp-elevating agents on these proteins in doxorubicin-trea...

background: dihydropyrimidinase related proteins (drps) have known homologous to the collapsing response mediator proteins (crmps). the drp gene family has comprised four members, drp 1, 2, 3, and 4, all out of which have considered to be involved in axonal outgrowth and path-finding. methods: the protein has extracted from tumor, normal brain tissues, and then the protein purity has evaluated ...

Chemical phosphorylation of hydrolysate resulting from hydrothermal carbonization chicken feather waste was performed to enhance the amino acids and reduce metal ions content. The aim this research is improve functional properties feathers without impairing nutritional availability thereof with cheapest chemical method by phosphorylation. Phosphorylated can function as animal feed fertilizer. o...

Glioma is one of the most common primary brain tumors, and mortality due to this disease second only cardiovascular cerebrovascular diseases. In traditional surgery, it difficult eradicate glioma; often recurrence increases its malignant degree, leading a large number patients killed by disease. It important subjects study pathogenesis explore effective treatment methods. Research on glioma mec...

protein tyrosine phosphatases (ptpases) regulate the tyrosine phosphorylation of target proteins in volved in several biological activities including cell proliferation and transformation. protein tyrosine phosphatase e (ptpe) contains duplicated ptpase-like domains and a short extracellular region. us ing the fluorescence in situ hybridization method, the gene encoding ptpe (locus symbol ptpre...

ABSTRACT The C-terminal of G protein-coupled receptors is now recognized as being important for protein activation and signaling function. To detect the role tail in receptor activation, we used α1b-AR, which has a long 164 amino acids. We constructed intramolecular FRET sensors, was truncated to 10 (∆C-10), 20 (∆C-20), 30 (∆C-30), 50 (∆C-50), 70 (∆C-70), or 90 (∆C-90). mutants ∆C-10, ∆C-20, ∆C...