Objective(s): Tuberculosis (TB) has still remained a global health issue. One third of the world's population is infected with tuberculosis and the current BCG vaccine has low efficiency; hence, it is necessary to develop a new vaccine against TB. The aim of the current study was to evaluate the efficiency of a novel DNA vaccine encoding Mtb32C-HBHA antigen in inducing specific immune responses...

Objective(s): Despite treatment with antibiotics and vaccination with BCG, tuberculosis (TB) is still considered as one of the most important public health problems in the world. Therefore, designing and producing a more effective vaccine against TB seems urgently. In this study, immunogenicity of a fusion protein which consisting or comprising CFP-10 from Mycobacterium tuberculosis and the Fc-...

The HIV-TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) can complicate combined treatments for HIV-1 and TB. Little is known about tissue damage in TB-IRIS. Matrix metalloproteinases (MMPs) degrade components of the extracellular matrix and consequently may play a role in such immunopathology. Here we investigated the involvement of MMPs in TB-IRIS. We determined MMP transcr...

Tuberculosis (TB) is an infectious disease worldwide that causes death. Common clinical manifestations of patients with TB include anemia, hypoalbuminemia, and malnutrition. Most are infected coccus bacteria, such as Staphylococcus aureus, commonly attack the respiratory tract. However, consumption heme protein sources could improve nutritional status TB. Fish comprise one most widely consumed ...

BACKGROUND Tuberculosis (TB) and HIV infection are wasting diseases that frequently occur together and have severe consequences on nutritional status. OBJECTIVE The objective was to determine the effects of TB and HIV, separately and together, on protein metabolism. DESIGN Protein metabolism was determined in the fed state in 11 healthy control subjects, in 10 patients with HIV infection wi...

Abstract The aim of the present study was to investigate effects milk composition changes on in vitro growth bovine mastitis pathogens. Nutritional requirements three major pathogens Escherichia coli ( E. ), Staphylococcus aureus S. and Streptococcus uberis ) were investigated . We used ultra-high temperature (UHT) treated with different contents fat, protein, carbohydrates test influence avail...

OBJECTIVE The diagnosis of tuberculosis (TB) ascites is problematic. Delay in the diagnosis and treatment of TB ascites are considered to be major factors that contribute to the high mortality of TB. This study identifies specific protein markers in ascitic fluid which will be useful in diagnosis of TB ascites. METHODS We used Two-Dimensional Electrophoresis, liquid chromatography-mass spectr...

BACKGROUND Biological parameters are useful tools for understanding and monitoring complicated disease processes. In this study, we attempted to identify proteins associated with active pulmonary tuberculosis (TB) using a proteomic approach. METHODS To assess TB-associated changes in the composition of human proteins, whole blood supernatants were collected from patients with active TB and he...

The early secretory antigenic target (ESAT)-6 purified protein and peptides from Mycobacterium tuberculosis were evaluated as antigens for the immunodiagnosis of tuberculosis (TB). Because the control of TB requires improved diagnostic procedures, efforts have increased to identify Mycobacterium tuberculosis-specific epitopes for the immunodiagnosis of active TB and to discriminate between acti...