echinococcosis is one of the world’s relevant zoonoses, affecting both humans and their domestic animals and caused by infection with the metacestode stage of the dog tapeworm, echinococcus granulosus. in the present study, twenty mice were randomly divided into 4 groups of 5. each mouse in groups 1, 2 and 3 was immunized with 100 μg of hydatid cyst fluid protein, protoscolex and adult worms of...

A full-length cDNA sequence coding for Echinococcus granulosus thioredoxin peroxidase (EgTPx) was isolated from a sheep strain protoscolex cDNA library by immunoscreening using a pool of sera from mice infected with oncospheres. EgTPx expressed as a fusion protein with glutathione S-transferase (GST) exhibited significant thiol-dependent peroxidase activity that protected plasmid DNA from damag...

OBJECTIVES Infection of humans and domestic ruminants with the larval stage (metacestode) of Echinococcus granulosus results in cystic echinococcosis (CE). The metacestode causes a space-occupying lesion in visceral organs, most commonly in the liver. Benzimidazole carbamate derivatives, such as mebendazole and albendazole, are currently used for chemotherapeutic treatment of CE. In human patie...

BACKGROUND Alveolar echinococcosis, caused by Echinococcus multilocularis larvae, is a chronic disease associated with considerable modulation of the host immune response. Dendritic cells (DC) are key effectors in shaping the immune response and among the first cells encountered by the parasite during an infection. Although it is assumed that E.multilocularis, by excretory/secretory (E/S)-produ...

Objective: Cystic echinococcosis (CE) is an important parasitic infection caused by Echinococcus granulosus (E. granulosus) larvae, adults of which live in Canidae. Although CE observed all over the world, it more prevalent developing and underdeveloped nations.
 Material Method: This study was conducted on a total 60 cyst samples, including 20 sheep cattle slaughtered abattoir patients op...

The efficacy of albendazole (50 mg/kg/d), mebendazole (50 mg/kg/d) and praziquantel (500 mg/kg/d) against established intraperitoneal infections of Echinococcus multilocularis in gerbils was compared by monitoring parasite weight and making ultrastructural observations on treated and untreated material. Praziquantel was the most active protoscolicidal agent, reducing protoscolex viability to le...

hydatidosis is a disease caused by infection with the metacestode stage of the dog tapeworm,echinococcus granulosus. this is recognised as one of the world’s most important zoonoses, affecting bothhumans and their domestic animals. in the current study, 20 sheep cystic livers or lungs were collected.hydatid fluid and protoscolices were isolated and the soluble protein was prepared. polypeptide ...