Severe persistent pruritus is a common, but incompletely characterized, complication of hydroxyethyl starch (HES) infusion. This retrospective study aimed to assess HES-induced pruritus by electron microscopic findings, pruritus characteristics, and response to stimuli, and to determine the impact of HES dosage, molecular weight and substitution. Seventy patients with electron micro-scopy-prove...

Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. The aim of this study was to identify factors associated with pruritus in these patients. Met...

background uremic pruritus is a common and bothersome complaint among end-stage renal disease which affect between 25% and 60% of this population .but there is no decisive cure for treatment of it. in this study, the effects of omega-3 for treatment of pruritus were investigated in hemodialysis patients. methods a double-blind randomized study was carried out in the form of placebo-controlled c...

BACKGROUND Pruritus affects many haemodialysis (HD) patients. In this study, pruritus and its relationship to morbidity, mortality, quality of life (QoL), sleep quality and patient laboratory measures were analysed in >300 dialysis units in 12 countries. METHODS Pruritus data were collected from 18 801 HD patients in the Dialysis Outcomes and Practice Patterns Study (DOPPS) (1996-2004). Analy...

Discovery of pruritus-specific mediators and receptors facilitated the neurobiological concept of pruritus: itch-specific (histamine-dependent and histamine-independent C-fibers); itch-specific receptors on cutaneous and spinal neurons; "dialogue" between the pruritus-specific neurons and cells in the skin; peripheral and central mediation of pruritus; functional "pruritus-specific matrix" in t...

OBJECTIVES One previous study has estimated the prevalence of pruritus in SSc, but that study had important limitations due to a relatively small sample size. The present study updates the analyses of the previous study using a substantially larger patient sample. The objectives were to (i) document the proportion of patients who experience pruritus on most days overall and by disease duration ...

Background: Pruritus is the most commonly occurring subjective symptom of dermatological disease. Published data on both prevalence and intensity of pruritus in psoriasis is limited. Objective: In this study we aimed to investigate the prevalence of pruritus and its relation with psoriasis area severity index, body mass index and presence of systemic disease in patients with psoriasis. Meth...

BACKGROUND Uremic pruritus is a common, but unpleasant, complication of end-stage renal disease. The uremic burden may differ between hemodialysis (HD) and peritoneal dialysis (PD) patients. This difference may also change the clinical characteristics of uremic pruritus between the 2 modalities. In this study, we investigated the uremic pruritus between patients on HD and PD. METHODS A total ...

BACKGROUND Uremic pruritus is the most frequent symptom in long-term hemodialysis patients. Abnormal laboratory parameters have been found with conflicting data. OBJECTIVE To correlate the prevalence of pruritus with alterations in mineral metabolism in hemodialysis patients. METHODS This was a case-control study. A hundred and five patients on maintenance hemodialysis were evaluated: a gro...