Insulin-loaded microemulsions for transdermal delivery were developed using isopropyl myristate or oleic acid as the oil phase, Tween 80 as the surfactant, and isopropyl alcohol as the cosurfactant. The pseudoternary phase diagrams were constructed to determine the composition of microemulsions. The insulin permeation flux of microemulsions containing oleic acid as oil phase through excised mou...

The present work was aimed to design and develop self-nanoemulsifying drug delivery systems (SNEDDS) with the objective to overcome the problems associated with the delivery of talinolol, a hydrophobic and poorly bioavailable drugs having pH dependant solubility. The solubility of talinolol in various oils, surfactants, cosurfactants and aqueous phases were determined to identify and select the...

clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (adp) to its platelet receptor and the subsequent adp-mediated activation of the glycoprotein gpiib/iiia complex, thereby inhibiting platelet aggregation. oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. the aim of this investigation was ...

Abstract
 The present investigation aimed to formulate a liquid self-microemulsifying drug delivery system (SMEDDS) of tacrolimus enhance its oral bioavailability by improving dispersibility and dissolution rate. Four SMEDDS were prepared using maisine CC as oil phase, labrasol ALF surfactant transcutol HP co-surfactant based on the solubility studies in these components. phase behavior co...

Atorvastatin is a BCS class II lipid lowering agent. It is insoluble in aqueous solution of pH 4 and below; it is very slightly soluble in water and pH 7.4 phosphate buffer. In the present investigation an attempt has been made to enhance solubility and dissolution of poorly soluble drug by formulating self microemulsifying drug delivery system (SMEDDS). The solubility of atorvastatin in indivi...

The aim of the study was to develop and evaluate a self--emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary ph...

Efavirenz is a drug with an absorption window. Its oral bioavailability is 40-50%. The aim of this work was to formulate solid self-emulsifying drug delivery system to improve the solubility and bioavailability of efavirenz. Solubility of Efavirenz was determined in various vehicles like oils, surfactants and co surfactants. Which, upon dilution with aqueous media, spontaneously form fine oil i...

Objective: The aim of this work was to establish pseudoternary phase diagrams for Palestinian basil extracts (seeds and leaves), formulate a microemulsion, study the antioxidant antimicrobial effects medicinal plant. Methods: Pseudoternary were prepared by utilizing water titration method, using leaves) as an oil phase. Basil analyzed its phytochemical constituents after it extracted Soxhlet ex...

Intercalation cotnpounds with one type of guest atom are pseudobinary systems as long as the host retains its structure, and the behavior of such compounds can often be understood with two-component models. '2 One component is then the guest and the other is the interstitial site where the guest resides. Similarly, intercalation compounds with two types of guests are pseudoternary systems. Addi...

Rapid construction of phase diagrams is a central tenet of combinatorial materials science with accelerated materials discovery efforts often hampered by challenges in interpreting combinatorial X-ray diffraction data sets, which we address by developing AgileFD, an artificial intelligence algorithm that enables rapid phase mapping from a combinatorial library of X-ray diffraction patterns. Agi...