objective(s): bacterial biofilm formation causes many persistent and chronic infections. the matrix protects biofilm bacteria from exposure to innate immune defenses and antibiotic treatments. the purpose of this study was to evaluate the biofilm formation of clinical isolates of pseudomonas aeruginosa and the activity of zinc oxide nanoparticles (zno nps) on biofilm. materials and methods: aft...

Abstract Background Pseudomonas aeruginosa is among the most important cause of life threatening hospital acquired infections. It considered as top listed public health threat worldwide due to its ability produce toxins, virulence factors, biofilms and resist multiple antibiotics. Biofilm formation a pathogenic mechanism harboured by this pathogen which further elevates resistance antibiotics h...

Objective(s): Bacterial biofilm formation causes many persistent and chronic infections. The matrix protects biofilm bacteria from exposure to innate immune defenses and antibiotic treatments. The purpose of this study was to evaluate the biofilm formation of clinical isolates of Pseudomonas aeruginosa and the activity of zinc oxide nanoparticles (ZnO NPs) on biofilm. Materials and Methods: Aft...

This investigation's goal was to find Pseudomonas aeruginosa virulence factors in canine wound infections. 100 samples were gathered and tested for eight variables utilizing biochemical molecular techniques this purpose. According the findings, women (72%) had highest isolation ratio. The found various ratios, with capsule being (16.6%) of them, amylase enzyme detected (3.3%), hemolysin (70%), ...

Groundwater fluoride contamination is one of the dominant toxicological environmental problems in India and overseas. Water samples were taken from Natham taluk screened resistant bacteria. Initially, Twenty- four colonies selected 50 mM NaF supplemented LB agar plates. All isolates showed ?-haemolysis on blood plates, confirmed as pathogens. Virulence factors (algD, plcH, toxA, gyrB, rhlC, las...

Dugesia tigrina is a non-parasitic platyhelminth, which has been recently utilized in pharmacological models, regarding the nervous system, as it presents a wide sensitivity to drugs. Our trials aimed to propose a model for an in vivo screening of substances with inhibitory activity of the enzyme acetylcholinesterase. Trials were performed with four drugs commercialized in Brazil: donepezil, ta...

In Pseudomonas aeruginosa, the production of many secreted virulence factors is controlled by a quorum-sensing (QS) circuit, constituted of transcriptional activators (LasR, RhlR, PqsR) and their cognate signaling molecules (3-oxo-C12-HSL, C4-HSL, PQS). QS is a cooperative behavior that is beneficial to a population but can be exploited by "QS-cheaters", individuals which do not respond to the ...


 Значне поширення резистентних штамів P. aeruginosa, здатність до плівкоутворення, складні регуляторні мережі формування біоплівок і багаточисельні фактори вірулентності потребують пошуку нових сполук розробки препаратів, які здатні порушувати біоплівок.
 Мета дослідження – вивчити експресію генів, що регулюють біоплівки aeruginosa за дії похідного адамантану.
 Антибіоплівкову а...