Objective(s): High Mobility Group Box1 (HMGB1) is a nonhistone, DNA-binding protein that serves a crucial role in regulating gene transcription and is involved in a variety of proinflammatory, extracellular activities. The aim of this study was to explore whether HMGB1 stimulation can up-regulate the expression of Toll-like Receptor 2 (TLR2) and Toll-like Receptor 4 (TLR4) on macrophages from p...

The purpose of the study was to histologically analyse transition from pulpitis to periapical periodontitis on dog's teeth. Pulps of mandibular premolars (37 roots) were exposed using a low-speed handpiece. Teeth were left open to the oral environment for 20, 35, 50 and 65 days. After the experimental period animals were sacrificed. Undemineralised teeth with surrounding bone, embedded in methy...

OBJECTIVES The purpose of this study was to determine the pain associated with needle insertion (with or without topical anesthetic) and solution deposition for the long buccal nerve block injection in patients with irreversible pulpitis. Initial pain and any differences by age and gender were also studied. STUDY DESIGN One hundred twelve emergency patients with irreversible pulpitis received...

This is a retrospective clinical study of 360 teeth diagnosed with pulpitis and treated locally with a combination of three antibacterial drugs (ciprofloxacin, metronidazole and minocycline, “3Mix-MP”) without a pulpectomy procedure. Consecutive patients with a clinical diagnosis of pulpitis had pre-operative factors collected (spontaneous pain, pulp exposure, depth of carious lesion) and were ...

Many studies have examined the pattern of various analgesics and antibiotics prescribed by primary care dental practitioners to treat irreversible pulpitis. To determine the pattern of medicines for irreversible pulpitis among undergraduate dental students, a cross sectional survey seeking mock medications based on dental scenarios of irreversible pulpitis for child, pregnant woman and apical p...

The objective of this equivalency study was to see if a colony of Streptococcus mutans placed into cavities in primary molar teeth produced pulpitis similar to an established pulpitis induction method using carious dentine. In two juvenile baboons (Papio ursinus), occlusal cavities were cut in all 16 primary molar teeth, followed by making a small pulpal exposure after which the cavity was swab...

BACKGROUND The aims of this study were to assess symptoms and signs caused by cracks in teeth and to assess a conservative management protocol. METHODS The symptoms and signs of 100 consecutive teeth that had reversible pulpitis associated with cracks were compared to findings from other reports. Teeth were managed with a conservative protocol which involved removal of cracks, caries and rest...

BACKGROUND Irreversible pulpitis is a highly painful inflammatory condition of the dental pulp which represents a common dental emergency. Recommended care is partial endodontic treatment. The dental literature reports major difficulties in achieving adequate analgesia to perform this emergency treatment, especially in the case of mandibular molars. In current practice, short-course, orally adm...

Radiograph plays the major role of diagnosis, treatment and surgery in Dental field. There are many types Intra extra oral radiographs which Panoramic helps visualising full view cavity. Pulpitis is dental diseases caused due to inflammation pulp from untreated caries, trauma or multiple restorations leads Apical Periodontitis. To predict severity vitality has be evaluated. Radiographs dentist ...

OBJECTIVES This study was done to compare the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine with that of 2% lidocaine with 1:80,000 epinephrine during pulpectomy in patients with irreversible pulpitis for inferior alveolar nerve block in mandibular posterior teeth. MATERIAL AND METHODS Patients with irreversible pulpitis referred to the Department of Conservative Dentistry an...