The analysis, "Graft Purging in Autologous Bone Marrow Transplantation: A Promise Not Quite Fulfilled," by Drs. Joseph Alvarnas and Stephen Forman, is very timely. The authors" conclusion is succinctly presented in their title. For about a decade late in the 20th century, the merits-or in some cases, the absolute necessity-of purging autologous bone marrow harvests prior to transplantation were...

This article focuses on prevention of possible exposure to chemical agents, when opening, entering, and stripping freight containers. The container purging process is investigated using tracer gas measurements and numerical airflow simulations. Three different container ventilation conditions are studied, namely natural, mixed mode, and forced ventilation. The tests conducted allow purging time...

This study applied a functional approach to the study of bingeing and purging behaviors. Based on a four-function theoretical model of bingeing and purging, it was hypothesized that these behaviors are performed because of their intrapersonally reinforcing (e.g., emotion regulation) and/or interpersonally reinforcing (e.g., help-seeking, attention-getting behavior) properties. Participants were...

BACKGROUND The comorbidity of purging behaviours, such as vomiting, inappropriate use of laxatives, diuretics or slimming medications, has been examined in literature. However, most studies do not include adolescents, individuals who purge in the absence of binge eating, or those purging at subclinical frequency. This study examines the prevalence of purging among 16-year-old girls across three...

Binge eating disorder and purging disorder have gained recognition as distinct eating disorder diagnoses, but risk factors for these conditions have not yet been established. This study aimed to evaluate a prospective, mediational model of risk for the full range of binge eating and purging eating disorders, with attention to possible diagnostic differences. Specific aims were to determine, fir...

Mating between related animals is an inevitable consequence of a closed population structure especially when it coincides with small size. As result, inbreeding depression may be encountered considering fitness traits. However, under certain circumstances, the joint effects and selection at least partly purge detrimental genes from population. In course this study, our objective was to determin...

OBJECTIVE To identify shared risk and protective factors for purging, binge eating, and overweight. DESIGN Prospective cohort study. SETTING Population-based questionnaires of children and adolescents residing across the United States. PARTICIPANTS Girls (n = 6022) and boys (n = 4518), aged 11 to 17 years in 1998, in the ongoing Growing Up Today Study. MAIN EXPOSURES Putative risk and p...

Clonogenic tumor cells contained within hematopoietic stem cell (HPC) grafts may contribute to relapse following autologous transplantation. Graft purging involves either in vivo or ex vivo HPC manipulation in order to reduce the level of tumor cell contamination. Some phase II trials suggest that patients who receive purged products may have a superior transplant outcome. Phase I trials demons...