A specific, simple, sensitive Ultra High Performance Liquid Chromatography-tandem Mass Spectrometry (UHPLC-MS/MS) method has been developed and validated for the simultaneous determination and pharmacokinetic study of purpurin, munjistin, and mollugin in rat plasma. Chromatographic separation was carried out using a C18 column (ACQUITY UPLC(®) HSS T3, 1.8 μm, 2.1 × 100 mm) with gradient elution...

Abstract This article describes two of the most common natural sources red anthraquinones that have been used since antiquity for textile dyeing and as lake pigments, namely cochineal insect roots Rubia Relbunium plants. Carminic acid is main component carmine, colorant obtained from cochineal. Alizarin purpurin are found in extracts roots, but contain only purpurin. These identified a variety ...

Purpurin is a major anthraquinone present in the roots of Rubia cordifolia (madder). known to activate Nrf2 (Nuclear transcription factor erythroid 2-related 2) EpRE (electrophile responsive element) mediated gene expression as potential beneficial effect. This study aimed elucidate balance between electrophilicity or pro-oxidant activity purpurin underlying induction. For this, activation with...

For possible future use in Photodynamic Therapy (PDT) and/or Photothermal Therapy (PTT) of cancer and screening of cancer cells a new type of ionic liquid photosensitizer -Cholinium-Purpurin-18 (Chol-Pu-18) - was synthesized and small gold (Au) nanoparticles, stabilized by this photosensitizer were prepared without adding any particular reducing agents and CTAB. UV-Vis spectroscopy and Transmis...

How to make cancer treatment more efficient and enhance the patient’s outcome? By multimodal therapy, theranostics, or personalized medicine? These are questions asked by scientists doctors worldwide. However, finding new unique approaches options for as well selective therapeutics is very challenging. More frequently, researchers “go back in time” use already known well-described compounds/dru...