The compound Pyrazole derivatives, is prepared from p – Amino benzoic acid and ethanol. Chalcone has been prepared by the condensation reaction of Ethyl-4-acetamido benzoate and different ten aldehydes. These chalcones are cyclized with hydrazine hydrate and glacial acetic acid under reflux condition give pyrazole derivatives. These compounds have been characterized by detailed spectral analysi...

A series of 3-aryl-1-phenyl-1H-pyrazole derivatives was synthesized in good yield and assayed in vitro as inhibitors of the mice acetylcholinesterase (AChE) and two goat liver monoamine oxidase (MAO) isoforms, MAO-A and MAO-B. Most of the compounds demonstrated a good AChE and selective MAO-B inhibitory activities in the nanomolar or low micromolar range. N-((3-(4-chlorophenyl)-1-phenyl-1H-pyra...

Pyrazole-containing compounds represent one of the most influential families N-heterocycles due to their proven applicability and versatility as synthetic intermediates in preparing relevant chemicals biological, physical-chemical, material science, industrial fields. Therefore, synthesizing structurally diverse pyrazole derivatives is highly desirable, various researchers continue focus on thi...

BACKGROUND The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole is an important scaffold in many insecticidal molecules. In an effort to discover new molecules with good insecticidal activity, a series of diacylhydrazine deriv...

Pyrazole is a five membered heterocyclic ring which is a versatile leading compound for designing potent bioactive agents. This interesting group of compounds has diverse biological activities such as antimicrobial, anti-inflammatory, analgesic, anticonvulsant, anticancer, anthelmintic, antioxidant and herbicidal. Results of numerous derivatives of different pyrazole and their substitutions are...

The quantum chemical and structure-based technique heuristic molecular lipophilicity potential (HMLP) is used in the liver alcohol dehydrogenase (LADH) study of molecular family pyrazole and derivatives. The molecular lipophilic index LM, molecular hydrophilic index HM, lipophilic indices lss, and hydrophilic indices hss of the substitutes (fragments), and atomic lipophilicity indices las are c...

Background: Pyrazole is a simple aromatic ring an organic compound of the heterocyclic series that characterized five-membered ring structure which comprises located adjacent two nitrogen atoms and three carbon atoms. In recent years interest in the pyrazole chemistry excessively has increased due to many a wide range of properties. Because they have a wide range of specific properties such as ...

The present work deals with the synthesis of acetoxysulfonamide pyrazole derivatives, substituted 4,5-dihydropyrazole-1-carbothioamide and 4,5-dihydropyrazole-1-isonicotinoyl derivatives starting from substituted vanillin chalcones. Acetoxysulfonamide pyrazole derivatives were prepared from the reaction of chalcones with p-sulfamylphenylhydrazine followed by treatment with acetic anhydride. At ...

The present work deals with the sequence of Novel Pyrazole fused Indole derivatives(4a-4l) were synthesized by simple conventional method andscreened for anthelmintic, antibacterial and anticancer activities. molecular docking studies also performed. All newly synthesizedcompounds structurally characterized on basis IR, 1HNMR Mass spectral analysis. Further, all prepared pyrazole fusedindole de...

A series of pyrazole carboxamide and isoxazolol pyrazole carboxylate derivatives were designed and synthesized in this study. The structures of the compounds were elucidated based on spectral data (infrared, proton nuclear magnetic resonance and mass spectroscopy). Then, all of the compounds were bioassayed in vitro against four types of phytopathogenic fungi (Alternaria porri, Marssonina coron...