The synthesis, characterization, and photophysical properties of two novel ligands, 5LINMe-1,2-HOPO (1) and H(2,2)-1,2-HOPO (2), which utilize the 1,2-HOPO chelate as a sensitizer for Eu(III) are reported. In addition, the former ligand was structurally characterized as the Eu(III) complex by X-ray crystallography. The [Eu(1)2]- complex of the tetradentate ligand (1) is stable in aqueous soluti...

In the title compound, C(37)H(34)N(2)O(2), the pyridinone ring adopts a half-chair conformation. In the octa-hydro-indolizine fused-ring system, the piperidine ring is in a chair conformation and the pyrrole ring is twisted about the N-C(piperidine) bond. The mol-ecular structure features a weak intra-molecular C-H⋯O inter-action.

A new approach to total syntheses of piperidine alkaloids (+)-241D, isosolenopsin and isosolenopsin A has been developed from D-alanine. The key step to access the chiral pyridinone intermediate was achieved via a gold mediated cyclization. Finally, various reduction conditions afforded the natural products in few steps and good overall yields.

In the mol-ecule of the title compound, C(15)H(19)NO(2), the six-membered dihydro-pyridinone ring assumes a screw-boat conformation. In the crystal structure, mol-ecules are linked via O-H⋯O hydrogen bonding between hydr-oxy and carbonyl groups, forming supra-molecular chains along the a axis.

In the title compound, C(37)H(30)Cl(4)N(2)O(2), the pyridinone ring adopts a twisted half-chair conformation. In the octa-hydro-indolizine fused-ring system, the piperidine ring is in a chair conformation and the pyrrole ring is twisted about the C-N bond linking the five- and six-membered rings. The mol-ecular structure features an intra-molecular C-H⋯O inter-action and the crystal packing is ...

In the title compound, C(21)H(16)N(4)O(2), the dihedral angle between the meth-oxy-substituted benzene ring and the ring system formed by the pyridinone ring and the pyrazole ring is 57.4 (1)°, and that between the unsubstituted phenyl ring and the ring system is 135.6 (1)°. In the crystal structure, mol-ecules are linked together via inter-molecular N-H⋯O hydrogen bonds.

The stability constants for the Fe(III) complexes of the orally active iron decorporation drug L1 (3-hydroxy-1,2-dimethyl-4-pyridinone) have been determined by potentiometric titration [glass electrode, 25.0 degrees C, mu = 0.15 mol/L (isotonic) NaCl]. A simple computer model of blood plasma (citrate 100 mumol/L, transferrin 37 mumol/L) has been used to compare the Fe(III) binding efficacies in...

A comprehensive survey of pathways leading to the generation of α-trifluoromethyl monocyclic piperidinic derivatives is provided (65 references). These compounds have been synthesized either from 6-membered rings e.g., pipecolic acid or lactam derivatives by introduction a trifluoromethyl group, from pyridine or pyridinone derivatives by reduction, and from 5-membered rings e.g., prolinol deriv...

The mol-ecule of the title compound, C11H9NO2, is essentially planar [r.m.s. deviation of the non-H atoms = 0.056 (1) Å]. In the crystal, strong O-H⋯O hydrogen bonds form zigzag chains along the b axis. The mol-ecules form stacks along the a axis due to π-π inter-actions, the shortest distance between the centroids of the benzene and pyridinone rings being 3.6146 (7) Å.

A 3-hydro-4-pyridinone compound derived from maltol and dopamine has been prepared using a microwave reactor. The molecular structure of the protonated product was confirmed by single crystal X-ray diffraction. Crystals were obtained from a saturated solution of methanol and belong to the triclinic space group P-1 with unit cell parameters a = 8.3801(11) Å; b = 9.2583(12) Å; c = 11.5671(15) Å; ...